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TranscriptomicsTranscription profiling by array of human ovarian cancer cells overexpressing PKA regulatory subunits
The regulatory subunit of cAMP-dependent protein kinase (PKA) exists in two isoforms, RI and RII, which distinguish the PKA isozymes, type I (PKA-I) and type II (PKA-II). Evidence obtained from a variety of different experimental approaches has shown that the relative levels of type I and type II PK...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12854 | biostudies-arrayexpress
UnknownDefining A-Kinase Anchoring Protein (AKAP) Specificity for the Protein Kinase A Subunit RI (PKA-RI).
Not available
S-EPMC4836982 | biostudies-literature
UnknownIntegrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons.
Not available
S-EPMC11006854 | biostudies-literature
UnknownStructure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity.
Not available
S-EPMC3090270 | biostudies-literature
UnknownThe Novel MuRF2 Target SNX5 Regulates PKA Activity Through Stabilization of RI-α and Controls Myogenic Differentiation.
Not available
S-EPMC12515711 | biostudies-literature
ProteomicsIdentifications of protein kinase A substrates with quantitative phosphoproteomics and primary-sequence based scoring.(forskolin)
Protein kinase A (PKA) is a serine/threonine kinase who plays essential roles in the complex signalling pathways. To better understand the functionalities, it is necessary to elucidate direct interplays between PKA and their substrates in living system. In order to screen them in a high-throughput m...
ORGANISM(S): Homo Sapiens (human) 
2018-02-14 | PXD005922 | JPOST Repository
ProteomicsIdentifications of protein kinase A substrates with quantitative phosphoproteomics and primary-sequence based scoring.(H-89)
Protein kinase A (PKA) is a serine/threonine kinase who plays essential roles in the complex signalling pathways. To better understand the functionalities, it is necessary to elucidate direct interplays between PKA and their substrates in living system. In order to screen them in a high-throughput m...
ORGANISM(S): Homo Sapiens (human) 
2018-02-15 | PXD005925 | JPOST Repository
TranscriptomicsDifferential gene expression to VEGF in aorta from wild-type and C42S PKARI knock-in mice
Angiogenesis is essential for tissue development, wound healing and tissue perfusion, with its dysregulation linked-to tumorigenesis, rheumatoid arthritis and heart disease. Here we show pro-angiogenic stimuli couple to NADPH oxidase-dependent generation of oxidants that catalyse an activating inter...
ORGANISM(S): Mus musculus 
2015-06-24 | E-GEOD-70216 | biostudies-arrayexpress
TranscriptomicsBipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
Human genomic studies have identified protein-truncating variants in AKAP11 associated with both bipolar disorder (BD) and schizophrenia (SCZ), implicating a shared disease mechanism driven by loss-of-function. AKAP11, a protein kinase A (PKA) adaptor, plays a key role in degrading the PKA-RI comple...
ORGANISM(S): Mus musculus 
2025-12-09 | GSE304457 | GEO
TranscriptomicsExploring the scope of TOR/PKA co-regulation in MDN
To identify genes co-regulated by TOR and PKA during growth in MDN BCY1, bcy1 deletion, TPK, and tpk1-3 deletion strains were grown in MDN with and without rapamycin treatment. Different combinations of these samples were examined.
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-01 | E-GEOD-3160 | biostudies-arrayexpress
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