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MetabolomicsATG9A-PLA2G6 axis reprograms phospholipid metabolism to drive metabolic liver disease and hepatocellular carcinoma

The liver orchestrates systemic metabolism, and its dysfunction drives diseases including metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC). ATG9A, an autophagy-related transmembrane protein and lipid scramblase, regulates lipid dynamics, yet its ...

2025-10-24 | MTBLS12451 | MetaboLights
MetabolomicsCommensal intestinal microbiota regulates host luminal proteolytic activity and intestinal barrier integrity through β-glucuronidase activity (Part 2)
Not available
ORGANISM(S): Mus musculus 
ST002090 | MetabolomicsWorkbench
TranscriptomicsHigh content imaging in the screening of biomaterial-induced MSC behavior
Upon contact with a biomaterial, cells and surrounding tissues respond in a manner dictated by the physicochemical and mechanical properties of the material. Traditionally, cellular responses are monitored using invasive analytical methods that report the expression of genes or proteins. These analy...
ORGANISM(S): Homo sapiens 
2018-11-10 | E-MTAB-7352 | biostudies-arrayexpress
UnknownAssociation of Lp-PLA(2) activity with allele-specific Lp(a) levels in a bi-ethnic population.
Not available
S-EPMC2914160 | biostudies-literature
UnknownGenome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
Not available
S-EPMC2861686 | biostudies-literature
UnknownThe single substitution I259T, conserved in the plasminogen activator Pla of pandemic Yersinia pestis branches, enhances fibrinolytic activity.
Not available
S-EPMC2715710 | biostudies-literature
UnknownNon-Mammalian Prdx6 Enzymes (Proteins with 1-Cys Prdx Mechanism) Display PLA₂ Activity Similar to the Human Orthologue.
Not available
S-EPMC6466579 | biostudies-literature
ProteomicsLong-term exposure to biodegradable polylactic acid microplastics promotes Microcystis aeruginosa proliferation
Biodegradable plastics, such as polylactic acid (PLA), are widely considered as sustainable alternatives to fossil fuel-derived polymers; however, their degradation generates polylactic acid microplastics (PLA-MPs), which raises ecological concerns in freshwater ecosystems. In this study, we investi...
ORGANISM(S): Microcystis Aeruginosa 
2025-10-15 | PXD069473 |
TranscriptomicsCombined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial
The obese, insulin resistant state is characterized by impairments in lipid metabolism. Dietary polyphenols might improve these deteriorations. We have previously shown that 3-days supplementation of combined Epigallocatechin-gallate and Resveratrol (E+R) increased energy expenditure, which was acco...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-71614 | biostudies-arrayexpress
UnknownPolylactide (PLA) as a Cell Carrier in Mesophilic Anaerobic Digestion—A New Strategy in the Management of PLA
Not available
S-EPMC9697477 | biostudies-literature
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