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TranscriptomicsHypothalamic gene expression profile indicates a reduction in G-protein signaling in the wfs1 mutant mice
WFS1 gene is coding protein with unknown function but its functional deficiency causes different neuropsychiatric and neuroendocrine syndromes. In the present study we aimed to find the functional networks influenced by the Wfs1 deficiency in the hypothalamus. We performed gene expression profiling ...
ORGANISM(S): Mus musculus 
2011-11-02 | E-GEOD-33372 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of temporal lobes of wfs1 deficient mice
Aim of present study was to describe the changes induced deletion of the Wfs1 gene in the temporal lobe of mice. Mutant mice were backcrossed to two different genomic backgrounds in order to exclude confounding foreign genomic background influence. Samples from temporal lobes were analyzed by using ...
ORGANISM(S): Mus musculus 
2010-04-06 | E-GEOD-15293 | biostudies-arrayexpress
TranscriptomicsReduced insulin secretion in WFS1-deficient mice may be related to downregulation of Trpm5
Wolfram syndrome, an autosomal recessive disorder characterized by juvenile-onset diabetes mellitus and optic atrophy, is caused by mutations in the WFS1 gene. WFS1 encodes an endoplasmic reticulum resident transmembrane protein. The Wfs1-null mice exhibit progressive insulin deficiency and diabetes...
ORGANISM(S): Mus musculus 
2015-02-14 | E-GEOD-65929 | biostudies-arrayexpress
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