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ProteomicsDiferential expression analyses PLAC8 defective cells
SARS-CoV-2 pandemic has caused a dramatic health, social and economic crisis worldwide. To better understand the host-virus interactions and identify potentially targetable host factors, we have conducted CRISPR-Cas9 genetic screens using SARS-CoV-2 pseudotyped lentiviruses on human lung cancer cell...
ORGANISM(S): Homo sapiens (Human) 
2022-09-06 | PXD036334 | Pride
Plac8 Covid 
TranscriptomicsPlac8-dependent and iNOS-dependent T cell-mediate mechanisms clear Chlamydia muridarum infections from the genital tract
Comparison of two Chlamydia-specific CD4 T cells that are dependent on iNOS to terminate Chlamydia replication in epithelial cells to two Chlamydia-specific CD4 T cells that are iNOS-independent: Chlamydia trachomatis urogenital serovars replicate predominately in epithelial cells lining the reprod...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-32128 | biostudies-arrayexpress
GenomicsTranscriptional change of HTR8/Svneo cells over expressed with PLAC8-EGFP
Transcriptional change of HTR8/Svneo cells over expressed with PLAC8-EGFP
PRJNA415391 | ENA
GenomicsPLAC8 attenuates pulmonary fibrosis and inhibits apoptosis of alveolar epithelial cells via facilitating autophagy
PLAC8 attenuates pulmonary fibrosis and inhibits apoptosis of alveolar epithelial cells via facilitating autophagy
PRJNA1188981 | ENA
GenomicsGenome-wide CRISPR Knockout Screen Identified PLAC8 as an Essential Factor for SADS-CoVs Infection
Genome-wide CRISPR Knockout Screen Identified PLAC8 as an Essential Factor for SADS-CoVs Infection
PRJNA827806 | ENA
UnknownThe novel KLF4/PLAC8 signaling pathway regulates lung cancer growth.
Not available
S-EPMC5964121 | biostudies-literature
TranscriptomicsPLAC8 attenuates pulmonary fibrosis and inhibits apoptosis of alveolar epithelial cells via facilitating autophagy
Idiopathic pulmonary fibrosis (IPF) is an irreversible lung condition that progresses over time, which ultimately results in respiratory failure and mortality. In this study, we found that PLAC8 was downregulated in the lungs of IPF patients based on GEO data, in bleomycin (BLM)-induced lungs of mic...
ORGANISM(S): Mus musculus 
2024-12-17 | GSE282477 | GEO
UnknownPlac8-ERK pathway modulation of monocyte function in sepsis.
Not available
S-EPMC11222481 | biostudies-literature
TranscriptomicsGenome-wide CRISPR Knockout Screen Identified PLAC8 as an Essential Factor for SADS-CoVs Infection
Zoonotic transmission of coronaviruses poses an ongoing threat to human populations. Endemic outbreaks of Swine Acute Diarrhea Syndrome Coronavirus (SADS-CoV) have caused severe economic losses in the pig industry and have the potential to cause human outbreaks. Currently, there are no vaccines or s...
ORGANISM(S): Homo sapiens 
2022-04-27 | GSE200982 | GEO
UnknownExcess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer.
Not available
S-EPMC4001536 | biostudies-literature
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