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ProteomicsPlanar Cell Polarity Core Protein Vangl
Vangl is a planar cell polarity (PCP) core protein essential for aligned cell orientation along the epithelial plane perpendicular to the apical-basal direction, which is important for tissue morphogenesis, development and collective cell behavior.
ORGANISM(S): Homo Sapiens 
PXD054233 |
ProteomicsLinking planar polarity signaling directly to actomyosin contractility during vertebrate neurulation
Actomyosin contractility represents an ancient feature of eukaryotic cells participating in many developmental and homeostasis events, including tissue morphogenesis, muscle contraction, and cell migration, with dysregulation implicated in various pathological conditions, such as cancer. At the mol...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2024-09-19 | PXD052350 | Pride
Planar cell polarity Dishevelled Exploris 480 Vertebrates Neurulation Proteomics Prickle Actomyosin contractility 
GenomicsSynthetic reconstitution of planar polarity initiation reveals principles of symmetry breaking across scales
Synthetic reconstitution of planar polarity initiation reveals principles of symmetry breaking across scales
PRJNA1511472 | ENA
UnknownA dual role for planar cell polarity genes in ciliated cells.
Not available
S-EPMC4121795 | biostudies-literature
ProteomicsThe Dynamic Proteome of Oligodendrocyte Lineage Differentiation Features Planar Cell Polarity and Macroautophagy Pathways
Generation of oligodendrocytes (OLs) is a sophisticated multistep process, mechanistic underpinnings of which are not fully understood and demand further investigation. To systematically profile proteome dynamics during human embryonic stem cell (hESC) differentiation into OLs, we applied in-depth q...
ORGANISM(S): Homo sapiens (Human) 
2020-09-16 | PXD017649 | Pride
Human embryonic stem cell  neural stem cell  progenitor cell  oligodendrocyte  wnt signaling  autophagy  quantitative proteomics  multiplexed tandem mass tag 
TranscriptomicsTranscriptome profiling of e11.25 mouse pancreas: comparison between Ngn3-/- and Ngn3-/- ; Pdx1::Ngn3ER TM pancreatic epithelium
Individual pancreatic buds of crosses between Ngn3+/- and Ngn3+/- ; Pdx1::Ngn3ER TM -IRES-GFP were dissected. Pregnant females were injected intra-peritoneal with 2mg of Tamoxifen at e10.25 (9 am) and dissected at e11.25 (9 to 11 am). Most of the mesenchymal tissue was removed to reduce the tissue c...
ORGANISM(S): Mus musculus 
2014-12-02 | E-MTAB-3139 | biostudies-arrayexpress
UnknownPAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow.
Not available
S-EPMC6123654 | biostudies-literature
GenomicsL1CAM generates SOX2+ metastatic progenitors through planar cell polarity signaling in lung adenocarcinoma
L1CAM generates SOX2+ metastatic progenitors through planar cell polarity signaling in lung adenocarcinoma
PRJNA1199024 | ENA
TranscriptomicsSynthetic reconstitution of planar polarity initiation reveals principles of symmetry breaking across scales
Development often relies on molecular prepatterning over large tissue scales, and how these patterns emerge is an essential question. Planar cell polarity (PCP), manifested as asymmetric distribution of junctional proteins within individual cells and coordinated across entire tissues, is a key modul...
ORGANISM(S): Canis lupus familiaris 
2026-10-02 | GSE343486 | GEO
UnknownCiliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea.
Not available
S-EPMC4302998 | biostudies-literature
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