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ProteomicsA deeply cA deeply conserved protease, acylamino acid-releasing enzyme (AARE), acts in ageing in Physcomitrella and Arabidopsis
Reactive oxygen species (ROS) are constant by-products of aerobic life. In excess, ROS lead to cytotoxic protein aggregates, which are a hallmark of ageing in animals and linked to age-related pathologies in humans. Acylamino acid-releasing enzymes (AARE) are bifunctional serine proteases, acting on...
ORGANISM(S): Physcomitrella 
2023-03-11 | PXD038742 | Pride
Plant ageing Ros Aging Physcomitrium Protein oxidation 
ProteomicsAdvanced glycation end products as markers of ageing in plants: glycation hotspots in the plant proteome
Glycation is a post-translational modification underlied by the interaction of protein amino and guanidino groups with carbonyl compounds like reducing sugars and α-dicarbonyls. In the first steps of this process, the protein amino groups react with reducing carbohydrates yielding the corresponding ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-06-19 | PXD006434 | Pride
Ages Plant proteomics Glycation 
GenomicsThe Circadian Clock in the Ageing Plant
The Circadian Clock in the Ageing Plant
PRJNA1015621 | ENA
ProteomicsGlobal protein oxidation profiling suggests efficient mitochondrial proteome homeostasis during ageing
The free radical theory of ageing is based on the idea that reactive oxygen species (ROS) may lead to the accumulation of age-related protein oxidation. Since the majority of cellular ROS is generated at the respiratory electron transport chain, this study focuses on the mitochondrial proteome of th...
ORGANISM(S): Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina) 
2016-02-24 | PXD001023 | Pride
Oxidative ptms Mitochondrial ageing Itraq Quantitative mass spectrometry Podospora anserina 
TranscriptomicsInfluence of human P53 on plant gene expression
Mammalian p53 is a super tumor suppressor and plays a key role in guarding genome from DNA damage. However, p53 has not been found in plants which do not bear cancer although they constantly expose to ionizing radiation of ultraviolet light. Here we introduced p53 into the model plant Arabidopsis an...
ORGANISM(S): Arabidopsis thaliana 
2016-06-26 | E-GEOD-79678 | biostudies-arrayexpress
TranscriptomicsThe Senescent Methylome and its relationship with cancer, ageing, and germline genetic variation in humans (gene expression)
Cellular senescence is a stable arrest of proliferation and is considered a key component of processes associated with carcinogenesis and other ageing-related phenotypes. However, till now, biological markers that define senescence on a genome-wide scale have been limited. Here, we report a DNA meth...
ORGANISM(S): Homo sapiens 
2015-07-26 | E-GEOD-56718 | biostudies-arrayexpress
TranscriptomicsThe Senescent Methylome and its relationship with cancer, ageing, and germline genetic variation in humans (methylation experiment 2)
Cellular senescence is a stable arrest of proliferation and is considered a key component of processes associated with carcinogenesis and other ageing-related phenotypes. However, till now, biological markers that define senescence on a genome-wide scale have been limited. Here, we report a DNA meth...
ORGANISM(S): Homo sapiens 
2015-07-26 | E-GEOD-69046 | biostudies-arrayexpress
TranscriptomicsThe Senescent Methylome and its relationship with cancer, ageing, and germline genetic variation in humans (methylation experiment 1)
Cellular senescence is a stable arrest of proliferation and is considered a key component of processes associated with carcinogenesis and other ageing-related phenotypes. However, till now, biological markers that define senescence on a genome-wide scale have been limited. Here, we report a DNA meth...
ORGANISM(S): Homo sapiens 
2015-07-26 | E-GEOD-56719 | biostudies-arrayexpress
TranscriptomicsThe Circadian Clock in the Ageing Plant
The plant circadian clock is linked to development on every scale, from control of the cell cycle to determination of flowering time. Of particular importance is the photoperiodic pathway, through which changes of day length (photoperiod) are interpreted. Circadian regulation of this pathway is gene...
ORGANISM(S): Arabidopsis thaliana 
2024-11-21 | GSE242964 | GEO
TranscriptomicsOntogenic Resistance in Apple
Ontogenic scab resistance in apple leaves and fruits is a horizontal resistance against the plant pathogen VenturiaM- inaequalis and is expressed as decrease of disease symptoms and incidence with the ageing of the leaves. Several studies at biochemical level tried to unveil the nature of this resis...
ORGANISM(S): Malus domestica 
2013-11-18 | E-MTAB-1726 | biostudies-arrayexpress
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