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TranscriptomicsRNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
The translational control of oncoprotein expression is implicated in many cancers. Here we report an eIF4A/DDX2 RNA helicase-dependent mechanism of translational control that contributes to oncogenesis and underlies the anticancer effects of Silvestrol and related compounds. For example, eIF4A promo...
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-56887 | biostudies-arrayexpress
GenomicsSystematic identification of G-quadruplex sensitive lethality by genome-wide genetic screening
A375 and HT1080 cells are treated with G-quadruplex ligands PDS or PhenDC3 following genome-wide shRNA knockdown. This enables the identification of genes that when silenced, specifically compromises cell growth in the presence of the ligand. First, a pilot screen was performed to determine a ligand...
ORGANISM(S): Homo sapiens 
2019-06-22 | E-MTAB-6367 | biostudies-arrayexpress
Proteomicsplant RNA G-quadruplexe proteomics screening
RNA G-quadruplexes (rG4s) are non-canonical RNA second structures formed by guanine (G)-rich sequences. They play important regulatory roles in both animals and plants through their structural dynamics and are closely related to human diseases and plant growth, development, and adaption. Here, prote...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-07-06 | PXD031877 | Pride
Arabidopsis thaliana Plant rna g-quadruplex Helicase 
UnknownRNA G-quadruplex structures exist and function in vivo in plants.
Not available
S-EPMC7466424 | biostudies-literature
TranscriptomicsrG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome
RNA structures are of crucial importance for biological function and gene regulation. Guanine (G)-rich sequences in RNA can assemble to form RNA G-quadruplex (rG4) structures; specific rG4s have been shown to regulate gene expression, and are associated with human diseases. However, no transcriptome...
ORGANISM(S): Homo sapiens 
2016-08-10 | E-GEOD-77282 | biostudies-arrayexpress
GenomicsArabidopsis thaliana strain:columbia
RNA G-quadruplex drives plant adaptation to cold
PRJNA762705 | ENA
UnknownRNA G-quadruplex structure contributes to cold adaptation in plants.
Not available
S-EPMC9585020 | biostudies-literature
UnknownG-Quadruplex in Gene Encoding Large Subunit of Plant RNA Polymerase II: A Billion-Year-Old Story.
Not available
S-EPMC8306923 | biostudies-literature
UnknownExploring the Relationship between G-Quadruplex Nucleic Acids and Plants: From Plant G-Quadruplex Function to Phytochemical G4 Ligands with Pharmaceutic Potential.
Not available
S-EPMC9698481 | biostudies-literature
UnknownG-quadruplex in the TMV Genome Regulates Viral Proliferation and Acts as Antiviral Target of Photodynamic Therapy.
Not available
S-EPMC10760922 | biostudies-literature
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