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MetabolomicsMetabolomics reveals molecular signatures for psoriasis biomarkers and drug targets discovery
Psoriasis is a chronic skin disease that affects multiple systems and can be influenced by immunological, environmental, and genetic factors. The discovery of plasma biomarkers of psoriasis and the regulation of metabolic pathways helps us understand psoriasis and may assist clinicians in the diagno...
2024-09-26 | MTBLS5185 | MetaboLights
TranscriptomicsGene expression in psoriasis lesions and uninvolved skin
Psoriasis is a chronic inflammatory skin disease characterized by marked proliferation of keratinocytes leading to pronounced epidermal hyperplasia, elongation of rete ridges and hyperkeratosis. The most common form of psoriasis, chronic plaque psoriasis (Psoriasis vulgaris), involves relatively sta...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-50790 | biostudies-arrayexpress
TranscriptomicsTranscriptional Landscape of Psoriasis Identifies the Involvement of IL36 and IL36RN
Background: In present study we performed whole transcriptome analysis in plaque psoriasis patients and compared lesional skin with non-lesional skin and with the skin from healthy controls. We sequenced total RNA from 12 lesional (LP), 12 non-lesional (NLP) and from 12 normal (C) skin biopsies. Res...
ORGANISM(S): Homo sapiens 
2015-04-24 | E-GEOD-66511 | biostudies-arrayexpress
TranscriptomicsExpression data from primary human keratinocytes exposed to cytokines in vitro (IL-4, IL-13, IL-17A, IFN-alpha, IFN-gamma, TNF)
The clinical features of psoriasis, characterized by sharply demarcated scaly erythematous plaques, are typically so distinctive that a diagnosis can easily be made on these grounds alone. However, there is great variability in treatment response between individual patients, and this may reflect het...
ORGANISM(S): Homo sapiens 
2012-03-07 | E-GEOD-36287 | biostudies-arrayexpress
TranscriptomicsExploring Molecular Determinants of Disease Progression in Psoriasis by Comparing Different Clinical Subtypes Having Similar Core Transcriptomes
To understand the mechanism of disease progression in psoriasis, we defined Asian small plaque psoriasis (small psoriasis) and Asian intermediate plaque psoriasis (intermediate psoriasis) as psoriasis subtypes with limited disease progression, and compared their cellular and molecular signatures wit...
ORGANISM(S): Homo sapiens 
2016-01-10 | E-GEOD-67853 | biostudies-arrayexpress
TranscriptomicsGuselkumab (interleukin-23-specific monoclonal antibody) demonstrates clinical and molecular response in moderate-to-severe psoriasis
A gene expression profiling study was conducted in which skin biopsy samples were collected for RNA extraction and hybridization to microarrays from patients with moderate-to-severe psoriasis who participated in the phase 1, guselkumab first-in-human randomized, double-blind, placebo-controlled tria...
ORGANISM(S): Homo sapiens 
2014-05-14 | E-GEOD-51440 | biostudies-arrayexpress
TranscriptomicsExpression data from skin biopsy samples from patients with moderate-to-severe psoriasis
A gene expression profiling sub-study was conducted in which skin biopsy samples were collected from 85 patients with moderate-to-severe psoriasis who were participating in ACCEPT, an IRB-approved Phase 3, multicenter, randomized trial. This analysis identified 4,175 probe-sets as being significantl...
ORGANISM(S): Homo sapiens 
2012-07-25 | E-GEOD-30999 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skin biposies (lesional and uninvolved) from psoriasis patients
Biopsies from uninvolved and from lesional skin of 13 patients with plaque-type psoriasis. Based on paired samples, 179 genes were more than 2-fold differentially expressed in lesional skin. Experiment Overall Design: Comparative RNA expression profiles from uninvolved and lesional skin of 13 patien...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-6710 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skin from psoriatic patients and normal controls
Gene expression has been proposed as an intermediate phenotype that can increase power in complex trait gene-mapping studies. Psoriasis, an immune-mediated, inflammatory and hyperproliferative disease of the skin and joints, provides an ideal model system to evaluate this paradigm, as conclusive evi...
ORGANISM(S): Homo sapiens 
2009-02-01 | E-GEOD-13355 | biostudies-arrayexpress
TranscriptomicsIL-17A is an essential cytokine to sustain pathogenic cell activation and inflammatory gene circuits in psoriasis vulgaris
In psoriasis, inflammation and epidermal hyperplasia are thought to be controlled by T cell-derived cytokines. Evidence now suggests that Th17 and Th22 cells infiltrate psoriasis lesions and by secreting IL-17 and IL-22, respectively, may drive disease-specific gene or cell responses. While studies ...
ORGANISM(S): Homo sapiens 
2012-01-31 | E-GEOD-31652 | biostudies-arrayexpress
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