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MetabolomicsUntargeted plasma metabolome identifies biomarkers in patients with extracranial arteriovenous malformations

OBJECTIVE: This study aimed to investigate the plasma metabolic profile of patients with extracranial arteriovenous malformations (AVM).

METHOD: Plasma samples were collected from 32 AVM patients and 30 healthy controls (HC). Ultra-high performance liquid c...

2023-10-30 | MTBLS7753 | MetaboLights
MetabolomicsUPLC-QTOF-MS-Based Plasma Lipidomic Profiling Reveals Biomarkers for Inflammatory Bowel Disease Diagnosis
Identification of new biomarkers may help in the early diagnosis of inflammatory bowel disease (IBD). In this study, ultrahigh-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was used to analyze the untargeted lipidomics and compare plasma l...
2021-10-18 | MTBLS1183 | MetaboLights
MetabolomicsIdentification and Validation of Plasma Lipid Biomarkers for Oral Cancer Diagnosis

Despite lipid metabolic changes in oral cancer (OC), their potential as diagnostic markers remains unclear. This study assessed the diagnostic potential of metabolites for OC detection. Plasma metabolites of patients with OC and healthy controls (HC) were profiled using untargeted and targeted me...

2026-05-02 | MTBLS12655 | MetaboLights
MetabolomicsPlasma Lipid Profile Reveals Plasmalogens as Potential Biomarkers for Colon Cancer Screening

In this era of precision medicine, there is an increasingly urgent need for highly sensitive tests for detecting tumors such as colon cancer (CC), a silent disease where the first symptoms may take 10-15 yr to appear. Mass spectrometry-based lipidomics is an emerging tool for such clinical diagno...

2023-11-13 | MTBLS1584 | MetaboLights
MetabolomicsAssessment of plasma metabolomic biomarkers in various pediatric diseases

BACKGROUND: Metabolites that are direct read-outs of the functional status of cells, tissues, and organs can be more closely associated with phenotype compared to other omics profiles. Previous studies showed the analytical validity of metabolomic platforms and demonstrated a uti...

2024-05-14 | MTBLS948 | MetaboLights
MetabolomicsGC-MS Based Plasma Metabolomics for Identification of Candidate Biomarkers for Hepatocellular Carcinoma in Egyptian Cohort
This study evaluates changes in metabolite levels in hepatocellular carcinoma (HCC) cases vs. patients with liver cirrhosis by analysis of human blood plasma using gas chromatography coupled with mass spectrometry (GC-MS). Untargeted metabolomic analysis of plasma samples from participants recruited...
2015-08-13 | MTBLS105 | MetaboLights
MetabolomicsNew plasma preparation approach to enrich metabolome coverage in untargeted metabolomics: plasma protein bound hydrophobic metabolite release with proteinase K
Plasma untargeted metabolomics is a common method for evaluation of the mechanisms underlying human pathologies and identification of novel biomarkers. The plasma proteins provide the environment for transport of hydrophobic metabolites. The current sample preparation protocol relies on the immediat...
2022-03-18 | MTBLS670 | MetaboLights
MetabolomicsPlasma Metabolome Analysis for Predicting Antiviral Treatment Efficacy in Chronic Hepatitis B: Diagnostic Biomarkers and Therapeutic Insights
The early and accurate identification of predictive biomarkers for antiviral treatment efficacy remains a significant clinical challenge, particularly in the management of chronic hepatitis B (CHB). This study aimed to assess whether the plasma metabolome could reliably predict the success of antivi...
2024-07-10 | MTBLS10401 | MetaboLights
MetabolomicsPCOS preterm plasma metabolome

This study investigated mid-trimester plasma metabolomic profiles in pregnant women to identify biomarkers associated with Polycystic Ovary Syndrome (PCOS) and preterm birth. A total of 149 participants were categorized into four groups: 32 with PCOS and preterm delivery, 34 with PCOS and term de...

2025-09-09 | MTBLS12968 | MetaboLights
MetabolomicsMetabolomics reveals molecular signatures for psoriasis biomarkers and drug targets discovery
Psoriasis is a chronic skin disease that affects multiple systems and can be influenced by immunological, environmental, and genetic factors. The discovery of plasma biomarkers of psoriasis and the regulation of metabolic pathways helps us understand psoriasis and may assist clinicians in the diagno...
2024-09-26 | MTBLS5185 | MetaboLights
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