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TranscriptomicsNetwork analysis identifies proinflammatory plasma cell polarization for secretion of ISG15 in human autoimmunity
Plasma cells (PCs) as effectors of humoral immunity produce immunoglobulins to match pathogenic insult. However, emerging data suggests more diverse roles for PCs as regulators of immune and inflammatory responses via secretion of factors other than immunoglobulins. The extent to which such response...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-75007 | biostudies-arrayexpress
TranscriptomicsSingle-cell immune repertoire sequencing of bone marrow plasma cells following infection and immunizations
We performed single-cell transcriptome and antibody repertoire sequencing of bone marrow plasma cells following protein (OVA and TNFR2) immunizations or infection with high dose LCMV clone 13.
ORGANISM(S): Mus musculus 
2021-12-01 | E-MTAB-11096 | biostudies-arrayexpress
TranscriptomicsTranscript profile comparison of Zbtb20-sufficient and Zbtb20-deficient polyclonal bone marrow plasma cells
ZBTB20 is an adjuvant-specific factor for long-term antibody responses. This factor is critical for maintaining long-lived plasma cells in alum-adjuvanted antibody responses but is dispensable for TLR ligand-adjuvanted responses. To identify the functions of ZBTB20 in long-lived plasma cells, we per...
ORGANISM(S): Mus musculus 
2014-06-19 | E-GEOD-58659 | biostudies-arrayexpress
GenomicsThe Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells
The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells
PRJNA787613 | ENA
TranscriptomicsTranscription profiling by array of human CD138 purified bone marrow plasma cells from relapsed multiple myeloma patients
Gene expression profiling of CD138 purified bone marrow plasma cells of relapsed multiple myeloma patients
ORGANISM(S): Homo sapiens 
2017-02-09 | E-MTAB-4715 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human CD138 purified bone marrow plasma cells from patients with multiple myeloma
Gene expression profiling of CD138 purified bone marrow plasma cells of previously untreated multiple myeloma patients
ORGANISM(S): Homo sapiens 
2017-02-09 | E-MTAB-4717 | biostudies-arrayexpress
TranscriptomicsBlimp1 controls plasma cell physiology and function
Antibody-secreting plasma cells are the terminal stage of the B-cell lineage. Plasma cell differentiation requires a major resetting of gene expression to silence the B cell transcriptional program, whilst establishing secretory function and long-term survival. The transcription factors Blimp1 and I...
ORGANISM(S): Mus musculus 
2016-01-18 | E-GEOD-70981 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human CD138 purified bone marrow plasma cells, CD27 memory B-cells, polyclonal plasmablastic cells and human myeloma cell lines
Gene expression profiling of CD138 purified bone marrow plasma cells of healthy donors, CD27 memory B-cells, cultured ployclonal plasmablastic cells and cultured human myeloma cell lines. Samples from healthy donors have been re-used from ArrayExpress experiment E-MEXP-2360. Some of the myeloma cell...
ORGANISM(S): Homo sapiens 
2017-02-23 | E-MTAB-5212 | biostudies-arrayexpress
MetabolomicsAMPK activation orchestrated replicative senescence of periodontal ligament stem cells via regulating metabolomics

BACKGROUND: Periodontal ligament mesenchymal stem cells (PDLSCs) are a promising cell resource for cell-based regenerative medicine in dentistry. PDLSCs inevitably acquire a senescent phenotype after prolonged in vitro expansion, and the key regulators of cells during replicative...

2022-11-15 | MTBLS4568 | MetaboLights
TranscriptomicsThe Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells
Antibody secretion by plasma cells provides acute and long-term protection against pathogens. The high secretion potential of plasma cells depends on the unfolded protein response, which is controlled by the transcription factor Xbp1. Here, we analyzed the Xbp1-dependent gene expression program of p...
ORGANISM(S): Mus musculus 
2022-10-18 | GSE190591 | GEO
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