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GenomicsNinjurins 1 Regulate Hematopoietic Stem Cell Amplification Through Canonical WNT Signaling Independently of Plasma Membrane Rupture Activity
Ninjurins 1 Regulate Hematopoietic Stem Cell Amplification Through Canonical WNT Signaling Independently of Plasma Membrane Rupture Activity
PRJNA1466307 | ENA
ProteomicsA Bioinspired Immunostimulatory System for Inducing Powerful Antitumor Immune Function by Directly Causing Plasma Membrane Rupture
Preparation of AMDs. 125 μM Ac4ManNAz were incubated with Raw 264.7 (~ 107 cells/dish) for 24, 48, and 72 h, followed by gentle washing with PBS or complete medium to produce Raw 264.7-Ac4ManNAz. Subsequently, Raw 264.7-Ac4ManNAz (~ 107 cells) were resuspended in PBS containing Alkynyl-Ce6(0.1 μM), ...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-21 | PXD050063 | Pride
Mouse Antitumor immune Plasma membrane rupture 
UnknownAutoinhibition of dimeric NINJ1 prevents plasma membrane rupture.
Not available
S-EPMC11711097 | biostudies-literature
UnknownNINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks.
Not available
S-EPMC11055670 | biostudies-literature
UnknownCharacterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis.
Not available
S-EPMC6126679 | biostudies-literature
TranscriptomicsLarge-scale downregulation of cytokeratins in amniotic epithelium after Group B Streptococcus choriodecidual infection in Macaca nemestrina: a pathway to PPROM
Early events leading to intrauterine infection remain poorly defined, but may hold the key to a therapeutic intervention for preterm delivery. To determine early molecular pathways associated with membrane weakening that may progress to preterm premature rupture of membranes (PPROM), we examined th...
ORGANISM(S): Macaca nemestrina 
2014-11-18 | E-GEOD-46290 | biostudies-arrayexpress
TranscriptomicsNinjurins 1 Regulate Hematopoietic Stem Cell Amplification Through Canonical WNT Signaling Independently of Plasma Membrane Rupture Activity
Ninjurin-1 (NINJ1), a protein recently linked to plasma membrane rupture (PMR) during inflammasome activation, plays a well-established role in cell death. However, its function in hematopoiesis has remained unexplored. In this study, we identify a novel, PMR-independent role for Ninj1 in regulating...
ORGANISM(S): Homo sapiens 
2026-07-02 | GSE330969 | GEO
UnknownMuscimol inhibits plasma membrane rupture and ninjurin-1 oligomerization during pyroptosis.
Not available
S-EPMC10556065 | biostudies-literature
UnknownStructural basis of NINJ1-mediated plasma membrane rupture in cell death.
Not available
S-EPMC10307626 | biostudies-literature
UnknownGlycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.
Not available
S-EPMC9754625 | biostudies-literature
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