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ProteomicsGrM - Human and mouse granzyme M display divergent and species-specific substrate specificities
Complementary positional proteomics of human and mouse granzyme M treated K-562 lysates
2012-05-23 | PRD000347 | Pride
ProteomicsSubstrate specificity divergence of granzyme tryptases.
Elucidating the true physiological functions of granzymes has been challenging since the origin of the granzyme studied, the use of non-physiological granzyme concentrations and the interspecies use of granzymes, with extrapolation of all these data to orthologous granzymes has led to inconsistencie...
ORGANISM(S): Homo sapiens (Human) 
2015-09-30 | PXD000570 | Pride
Proteomics Granzyme N-terminal cofradic Protease Specificity profile 
UnknownIdentification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A.
Not available
S-EPMC3979379 | biostudies-literature
UnknownImportance of extended protease substrate recognition motifs in steering BNIP-2 cleavage by human and mouse granzymes B.
Not available
S-EPMC4169252 | biostudies-literature
ProteomicsNeoantigen targeted dendritic cell vaccine generates durable T cell responses exhibiting the full spectrum of differentiation states in NSCLC patients
Background. Dendritic cell (DC)-based neoantigen vaccination holds potential as a safe and effective adjuvant therapy for patients with early-stage, resectable NSCLC, a tumor type typically characterized by high mutational loads. DCs have the unique ability to elicit robust antitumoral T-cell respon...
ORGANISM(S): Homo sapiens (Human) 
2024-03-17 | PXD044799 | Pride
Cancer Lung non-small cell carcinoma Vaccine Neoantigen Human 
UnknownGranzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis.
Not available
S-EPMC3921589 | biostudies-literature
UnknownConservation of the extended substrate specificity profiles among homologous granzymes across species.
Not available
S-EPMC3790301 | biostudies-literature
ProteomicsA simple peptide quantification approach for MS-based proteomics quality control
Despite its growing popularity and use, bottom-up proteomics remains a complex analytical methodology. Its general workflow consists of three main steps: sample preparation, liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) and computational data analysis. Quality assessment of th...
ORGANISM(S): Homo sapiens (Human) 
2020-07-28 | PXD014524 | Pride
Method optimization Bottom-up proteomics Peptide quantitation Quality control 
ProteomicsGranzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis in cancer cells
Cytotoxic lymphocyte protease granzyme M (GrM) is a potent inducer of tumor cell death in vitro and in vivo. The apoptotic phenotype and mechanism by which it induces cell death however, remain poorly understood and controversial. Here, we show that GrM-induced cell death was largely caspase-depende...
ORGANISM(S): Homo sapiens (Human) 
2013-11-27 | PXD000252 | Pride
Human Lc-msms Granzyme m 
ProteomicsConservation of the extended substrate specificity profiles among homologous granzymes across species
Granzymes are a family of structurally related serine proteases involved in immunity. To date four out of five human granzymes have been assigned orthologues in mice; however for granzyme H, no clear murine orthologue has been suggested and its role in cytotoxicity remains controversial. In this stu...
ORGANISM(S): Mus musculus (Mouse) 
2013-11-27 | PXD000152 | Pride
Lc-msms N-terminal cofradic Granzyme h Granzyme c Human Mouse 
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