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Pleiotropic effects of trans-regulatory mutations on gene expression and fitness
Pleiotropic Fitness Effects of the lncRNA Uhg4 in Drosophila melanogaster
Inflammation, oxidative and dicarbonyl stress play important roles in the pathophysiology of type 2 diabetes. Metformin is the first-line drug of choice for the treatment of type 2 diabetes because it effectively suppresses gluconeogenesis in the liver, however, its “pleiotropic“ effects remain cont...
ORGANISM(S): Rattus norvegicus 
Variation in gene expression arises from cis- and trans-regulatory mutations, which contribute differentially to expression divergence. Here, we compare the impacts on gene expression and fitness for cis- and trans-regulatory mutations affecting expression of the TDH3 gene in Saccharomyces cerevisia...
ORGANISM(S): Saccharomyces cerevisiae 
2021-05-25 | GSE175398 | GEO
Gene expression data from VHL teratomas comparing genes differentially expressed based on apoptotic response to tumor microenvironment. Abstract BACKGROUND: The risk relevance of the P81S von Hippel-Lindau (VHL) gene hotspot mutation identified in clear cell renal cell carcinoma from individuals ex...
ORGANISM(S): Mus musculus 
Pleiotropic effects of PhaR regulator in Bradyrhizobium diazoefficiens microaerobic metabolism
Pleiotropic effects of the rne∆MTS allele on RNA degradation
The Pleiotropic Effects of c-di-GMP content in Pseudomonas syringae
DCP (2-4-dichlorophenol; 0,3mM) and POELE (polyoxyethylen-9-laurylether; 0,1mM)treatment on Saccharomyces cerevisiae W303-1A wild-type cells. Further investigation of the involvement of the transcripton factors Pdr1 and Pdr3 in DCP treated cells. Cells were growing in early exponential phase in ric...
ORGANISM(S): Saccharomyces cerevisiae 
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