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MetabolomicsDe Novo Pyrimidine Synthesis Is a Collateral Metabolic Vulnerability in NF2-deficient Mesothelioma

Pleural mesothelioma (PM) is one of the deadliest cancers, with limited therapeutic options due to its therapeutically intractable genome, which is characterized by the functional inactivation of tumor suppressor genes (TSGs) and high tumor heterogeneity, including diverse metabolic adaptations. ...

2025-07-07 | MTBLS12461 | MetaboLights
ProteomicsMalignant pleural mesothelioma targeted proteomics signature from blood
Targeted proteomics based blood biomarkers for malignant pleural mesothelioma cancer
ORGANISM(S): Homo Sapiens 
2020-08-03 | PXD018457 | panorama
TranscriptomicsTranscription profiling of human pleural mesothelioma versus parietal and visceral pleura
Genome-wide profile of pleural mesothelioma versus parietal and visceral pleura
ORGANISM(S): Homo sapiens 
2009-01-01 | E-MTAB-47 | biostudies-arrayexpress
TranscriptomicsmRNA profiling by array of malignant pleural mesothelioma
A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net: mRNA profiles were obtained using HumanGeneChip HG-U133 Plus 2.0 arrays (Affymetrix) for the 67 samples from the study (63 MPM tumors and 4 normal pleural samples). We used th...
ORGANISM(S): Homo sapiens 
2019-05-23 | E-MTAB-6877 | biostudies-arrayexpress
TranscriptomicsMesothelioma tumor aCGH profiles
Malignant pleural mesotheliomas (MPMs) often show CDKN2A and NF2 inactivation but other highly recurrent mutations have not been described. To identify additional driver genes, we used an integrated genomic analysis of 53 MPM tumor samples to guide a focused sequencing effort that uncovered somatic ...
ORGANISM(S): Homo sapiens 
2011-09-25 | E-GEOD-29902 | biostudies-arrayexpress
TranscriptomicsIntegrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma
This SuperSeries is composed of the following subset Series: GSE20989: Mesothelioma integrative genomics: DNA methylation GSE21057: Copy number alterations in pleural mesothelioma Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-21058 | biostudies-arrayexpress
TranscriptomicsHuman Mesothelioma MicroRNA Study Part 1
MicroRNA expression profiles of malignant pleural mesothelioma (MPM) specimens were analyzed to identify novel microRNA that are potentially involved in the oncogenic transformation of human pleural cells. In addition to several novel MPM-associated microRNAs, we observed that the expression level ...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-40345 | biostudies-arrayexpress
ProteomicsMesothelioma-associated fibroblasts enhance proliferation and migration of malignant pleural mesothelioma cells via Met/PI3K and WNT signaling but do not protect against cisplatin_Secreted proteins
Introduction: Malignant pleural mesothelioma (MPM) is an aggressive malignancy with poor prognosis. Unlike many other cancers, MPM is mostly characterized by inactivation of tumor suppressor genes. Its highly malignant nature in absence of tumor driving oncogene mutations indicates an extrinsic supp...
ORGANISM(S): Homo sapiens (Human) 
2023-06-20 | PXD035987 | Pride
Human malignant pleural mesothelioma-associated fibroblasts (cafs) High-resolution timstof-based proteomics analyses Cisplatin 
GenomicsWhole Genome Sequencing of Mesothelioma Cell Lines
Malignant pleural mesothelioma (MPM) is characterized by dismal prognosis. Consequently, dissection of the molecular mechanisms driving malignancy is of key importance. Here we investigate whether activating mutations in the telomerase reverse transcriptase (TERT) gene promoter are present in MPM an...
ORGANISM(S): Homo sapiens 
2020-05-03 | E-MTAB-8989 | biostudies-arrayexpress
ProteomicsMesothelioma-associated fibroblasts enhance proliferation and migration of malignant pleural mesothelioma cells via Met/PI3K and WNT signaling but do not protect against cisplatin_Cytoplasmic proteins
Introduction: Malignant pleural mesothelioma (MPM) is an aggressive malignancy with poor prognosis. Unlike many other cancers, MPM is mostly characterized by inactivation of tumor suppressor genes. Its highly malignant nature in absence of tumor driving oncogene mutations indicates an extrinsic supp...
ORGANISM(S): Homo sapiens (Human) 
2023-06-20 | PXD036017 | Pride
Human malignant pleural mesothelioma-associated fibroblasts (cafs) High-resolution timstof-based proteomics analyses Cisplatin 
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