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MetabolomicsDe Novo Pyrimidine Synthesis Is a Collateral Metabolic Vulnerability in NF2-deficient Mesothelioma

Pleural mesothelioma (PM) is one of the deadliest cancers, with limited therapeutic options due to its therapeutically intractable genome, which is characterized by the functional inactivation of tumor suppressor genes (TSGs) and high tumor heterogeneity, including diverse metabolic adaptations. ...

2025-07-07 | MTBLS12461 | MetaboLights
ProteomicsMalignant pleural mesothelioma targeted proteomics signature from blood
Targeted proteomics based blood biomarkers for malignant pleural mesothelioma cancer
ORGANISM(S): Homo Sapiens 
2020-08-03 | PXD018457 | panorama
TranscriptomicsMesothelioma tumor aCGH profiles
Malignant pleural mesotheliomas (MPMs) often show CDKN2A and NF2 inactivation but other highly recurrent mutations have not been described. To identify additional driver genes, we used an integrated genomic analysis of 53 MPM tumor samples to guide a focused sequencing effort that uncovered somatic ...
ORGANISM(S): Homo sapiens 
2011-09-25 | E-GEOD-29902 | biostudies-arrayexpress
TranscriptomicsmRNA profiling by array of malignant pleural mesothelioma
A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net: mRNA profiles were obtained using HumanGeneChip HG-U133 Plus 2.0 arrays (Affymetrix) for the 67 samples from the study (63 MPM tumors and 4 normal pleural samples). We used th...
ORGANISM(S): Homo sapiens 
2019-05-23 | E-MTAB-6877 | biostudies-arrayexpress
TranscriptomicsHuman Mesothelioma MicroRNA Study Part 1
MicroRNA expression profiles of malignant pleural mesothelioma (MPM) specimens were analyzed to identify novel microRNA that are potentially involved in the oncogenic transformation of human pleural cells. In addition to several novel MPM-associated microRNAs, we observed that the expression level ...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-40345 | biostudies-arrayexpress
GenomicsWhole Genome Sequencing of Mesothelioma Cell Lines
Malignant pleural mesothelioma (MPM) is characterized by dismal prognosis. Consequently, dissection of the molecular mechanisms driving malignancy is of key importance. Here we investigate whether activating mutations in the telomerase reverse transcriptase (TERT) gene promoter are present in MPM an...
ORGANISM(S): Homo sapiens 
2020-05-03 | E-MTAB-8989 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human malignant pleural mesothelioma tumors and cell lines
Malignant pleural mesothelioma (MPM) is a highly lethal, poorly understood neoplasm that is typically associated with asbestos exposure. We performed transcriptional profiling using high-density oligonucleotide microarrays containing approximately 22,000 genes to elucidate potential molecular and pa...
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2549 | biostudies-arrayexpress
ProteomicsPrimary and hTERT-transduced mesothelioma-associated fibroblasts but not primary or hTERT-transduced mesothelial cells stimulate growth of human mesothelioma cells_Secreted proteins
Introduction: Pleural mesothelioma (PM) is known as one of the most aggressive malignancies among all cancers, despite of usually absent tumor-driver mutations in oncogenes. It develops in a unique inflammatory tumor microenvironment (TME), which has been postulated as major contributor of PM’s high...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043511 | Pride
Htert Mesothelioma-associated fibroblasts Pleural mesothelial cells Pleural mesothelioma Conditioned medium Human telomerase reverse transcriptase Tumor microenvironment 
ProteomicsPrimary and hTERT-transduced mesothelioma-associated fibroblasts but not primary or hTERT-transduced mesothelial cells stimulate growth of human mesothelioma cells_ Cytoplasmic proteins & Proteins from nuclear extracts
Introduction: Pleural mesothelioma (PM) is known as one of the most aggressive malignancies among all cancers, despite of usually absent tumor-driver mutations in oncogenes. It develops in a unique inflammatory tumor microenvironment (TME), which has been postulated as major contributor of PM’s high...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043534 | Pride
Htert Mesothelioma-associated fibroblasts Pleural mesothelial cells Pleural mesothelioma Conditioned medium Human telomerase reverse transcriptase Tumor microenvironment 
TranscriptomicsReal-time quantitative PCR analysis of human malignant pleural mesothelioma tissue specimens
BACKGROUND: Malignant pleural mesothelioma (MPM) is difficult to distinguish from reactive mesothelial proliferations (RMPs). MicroRNAs (miRNAs) are small non-coding RNA-strands (~22 nucleotides) that post-transcriptionally regulate gene-expression. Studies have shown that miRNAs are potential diagn...
ORGANISM(S): Homo sapiens 
2014-01-25 | E-GEOD-54394 | biostudies-arrayexpress
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