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TranscriptomicsOverexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity
Aims/hypothesis: While lipid deposition in skeletal muscle is considered to be involved in obesity-associated insulin resistance, neutral intramyocellular lipid (IMCL) accumulation per se does not necessarily induce insulin resistance. We previously demonstrated that overexpression of the lipid drop...
ORGANISM(S): Rattus norvegicus 
2013-01-29 | E-GEOD-43832 | biostudies-arrayexpress
ProteomicsIdentification of Plin5 binding partners involved in lipid droplet-mitochondrial contacts
Perilipin 5 (Plin5) has been shown the induce contact between mitochondria and lipid droplets, though the mechanism by which this occurs is unknown. It has been shown that the unique C-terminal domain of Plin5 is responsible for inducing these contact sites. In this proteomics study, we identify bin...
ORGANISM(S): Homo sapiens (Human) 
2023-04-06 | PXD031591 | Pride
Metabolism Plin5 Ap-ms 
GenomicsPhosphorylation of PLIN5 is dynamically regulated in mice, required for IRS2 expression in the male mice liver, but dispensable for PGC1a target genes previously associated with PLIN5
Phosphorylation of PLIN5 is dynamically regulated in mice, required for IRS2 expression in the male mice liver, but dispensable for PGC1a target genes previously associated with PLIN5
PRJNA1152100 | ENA
TranscriptomicsCardiomyocyte specific plin5 over expression
Presence of ectopic lipid droplets (LDs) in cardiac muscle is associated to lipotoxicity and tissue dysfunction. However, presence of LDs in heart is also observed in physiological conditions, such as at times when cellular energy needs and energy production from mitochondria fatty acid (FA) β-oxida...
ORGANISM(S): Mus musculus 
2013-02-09 | GSE44192 | GEO
UnknownPlin5/p-Plin5 Guards Diabetic CMECs by Regulating FFAs Metabolism Bidirectionally.
Not available
S-EPMC6854993 | biostudies-literature
TranscriptomicsCardiomyocyte specific plin5 over expression
Presence of ectopic lipid droplets (LDs) in cardiac muscle is associated to lipotoxicity and tissue dysfunction. However, presence of LDs in heart is also observed in physiological conditions, such as at times when cellular energy needs and energy production from mitochondria fatty acid (FA) ?-oxid...
ORGANISM(S): Mus musculus 
2013-02-09 | E-GEOD-44192 | biostudies-arrayexpress
TranscriptomicsPhosphorylation of PLIN5 is dynamically regulated in mice, required for IRS2 expression in the male mice liver, but dispensable for PGC1a target genes previously associated with PLIN5
Perilipin 5 (PLIN5) is a lipid droplet (LD) protein highly expressed in tissues that are active in fatty acid oxidation such as the heart, oxidative muscle, the liver, and brown adipocytes. PLIN5 shares homology with PLIN1: it prevents lipolysis in basal state but promotes lipolysis upon the activat...
ORGANISM(S): Mus musculus 
2024-08-26 | GSE275608 | GEO
UnknownHepatic PLIN5 Deficiency Impairs Lipogenesis through Mitochondrial Dysfunction.
Not available
S-EPMC9779494 | biostudies-literature
UnknownCardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility.
Not available
S-EPMC9887753 | biostudies-literature
UnknownPLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle.
Not available
S-EPMC4142393 | biostudies-literature
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