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ProteomicsHDL proteome remodeling post-stroke
Prospective cohort studies and meta-analyses examining the relationship between HDL-cholesterol (C) and stroke risk are discordant and question the value of HDL-C as a marker for stroke risk prediction. However, the relationship between other metrics of HDL, function and proteome, and stroke remain ...
ORGANISM(S): Homo Sapiens 
2021-01-24 | PXD015001 | panorama
ProteomicsExtended multiplexing of TMT labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue
Age-related and/or high caloric intake driven changes in visceral adipose tissue contribute to the development of diabetes and cardiovascular disease. The lack of reliable, high-throughput methods to analyze the adipose tissue protein composition has limited our understanding of the protein network...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-07-03 | MSV000082569 | MassIVE
ProteomicsTumour mtDNA mutations drive aerobic glycolysis to enhance checkpoint blockade (part 2)
Mitochondrial DNA (mtDNA) encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutations in the cancer genome, with truncating mutations in complex I genes being over-represented1 . While mtDNA mutations have been associ...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-08 | PXD044987 | Pride
Melanoma Cancer Complex i Mitochondrial dna 
ProteomicsBiomechanical rigidity and quantitative proteomics analyses of segmental regions of the ocular trabecular meshwork at physiologic and elevated pressures
The extracellular matrix (ECM) of the ocular trabecular meshwork (TM) builds resistance to aqueous humor outflow, thereby regulating intraocular pressure (IOP). Glaucoma, a leading cause of blindness worldwide, is associated with changes in the ECM of the TM. The elastic modulus indicates glaucomato...
ORGANISM(S): Homo sapiens (Human) 
2018-01-22 | PXD006424 | Pride
Glaucoma Biomechanical rigidity High resolution mass spectrometry Multi-notch isolation Extended multiplexing Trabecular mesh Quantitative proteomics Human Tandem mass tags 
ProteomicsA framework for quality control in quantitative proteomics
A thorough evaluation of the quality, reproducibility, and variability of bottom-up proteomics data is necessary at every stage of a workflow, from planning to analysis. We share vignettes applying adaptable quality control (QC) measures to assess sample preparation, system function, and quantitativ...
ORGANISM(S): Homo Sapiens Mus Musculus Bos Taurus Saccharomyces Cerevisiae 
2024-10-01 | PXD051318 | panorama
ProteomicsA Peptide-Centric Quantitative Proteomics Dataset for the Phenotypic Assessment of Alzheimer’s Disease
Alzheimer’s disease (AD) is a looming public health disaster with limited interventions. Desperately needed progress in therapeutic development rests on more detailed understanding of molecular pathogenesis. The vast majority of existing data for AD pathogenesis in humans is from standard neuropatho...
ORGANISM(S): Homo Sapiens 
2023-04-18 | PXD034525 | panorama
ProteomicsMag-Net: Rapid enrichment of membrane-bound particles enables high coverage quantitative analysis of the plasma proteome
Membrane-bound particles in plasma are composed of exosomes, microvesicles, and apoptotic bodies and represent ~1-2% of the total protein composition. Proteomic interrogation of this subset of plasma proteins augments the representation of tissue-specific proteins, representing a “liquid biopsy,” wh...
ORGANISM(S): Homo Sapiens 
2025-07-02 | PXD042947 | panorama
ProteomicsEvaluation of a modified Orbitrap Astral Zoom prototype for quantitative proteomics - Beyond identification lists
Mass spectrometry instrumentation continues to evolve rapidly, yet quantifying these advances beyond conventional peptide and protein detections remains challenging. Here, we evaluate a modified Orbitrap Astral Zoom mass spectrometer (MS) prototype and compare its performance to the standard Orbitra...
ORGANISM(S): Homo Sapiens Gallus Gallus 
2025-10-22 | PXD064536 | panorama
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