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Pseudomonas aeruginosa colonises the upper airway of cystic fibrosis (CF) patients, providing a reservoir of host-adapted genotypes that subsequently establish chronic lung infection. We previously experimentally-evolved P. aeruginosa in a murine model of respiratory tract infection and observed mut...
ORGANISM(S): Pseudomonas aeruginosa 
2018-07-11 | PXD009705 | Pride
Evolutionary trade-offs associated with pmrB mutations in host-adapted Pseudomonas aeruginosa
The purpose of the study was to examine the role of the elements of PmrA/PmrB two-component system in the global regulation of gene expression in L.pneumophia during axenic growth. Towards this goal pmrA and pmrB isogenic mutants were constracted in L. pneumophila strain AA100 using allelic exchange...
ORGANISM(S): Legionella pneumophila Legionella pneumophila subsp. pneumophila str. Philadelphia 1 
2008-12-23 | GSE13323 | GEO
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