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TranscriptomicsPCR array of inflammatory cytokines and receptors in mouse lungs with NF-kappaB RelA mutant in alveolar epithelial cells during pneumococcal pneumonia
A murine model of RelA mutated throughout the alveolar epithelium was generated. Mice were anesthetized and intratracheally instilled with 106 CFU of Streptococcus pneumoniae serotype 3 into the left lung lobe. Mice were euthanized after 15 hours after instillation, and left lung lobes were collecte...
ORGANISM(S): Mus musculus 
2012-08-03 | E-GEOD-38399 | biostudies-arrayexpress
TranscriptomicsPneumonia infection, lung and liver inflammation
Vaccination reduces morbidity and mortality from pneumonia but its effect on the tissue-level response to infection is still poorly understood. We evaluated pneumonia disease progression, acute phase response and lung gene expression profiles in mice inoculated intranasally with virulent gram-positi...
ORGANISM(S): Mus musculus 
2013-03-29 | E-GEOD-45644 | biostudies-arrayexpress
TranscriptomicsHepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia
Transcriptional effects in liver, lung and blood samples from mice after intratracheal challenge with either Streptococcus pneumoniae serotype 19 (lobar-pneumonia) or serotype 2 (sepsis) were monitored after 6 and 24 hours and compared to sham (vehicle control). We gratefully acknowledge the BMBF gr...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-26472 | biostudies-arrayexpress
TranscriptomicsIdentification of Genes That Contribute to the Pathogenesis of Invasive Pneumococcal Disease by In Vivo Transcriptomic Analysis
Streptococcus pneumoniae (the pneumococcus) continues to be responsible for a high level of global morbidity and mortality resulting from pneumonia, bacteremia, meningitis, and otitis media. Here we have used a novel technique involving niche-specific, genome-wide in vivo transcriptomic analyses to ...
ORGANISM(S): Streptococcus pneumoniae 
2012-07-20 | E-BUGS-133 | biostudies-arrayexpress
TranscriptomicsAn antibody to Streptococcus pneumoniae capsular polysaccharide enhances quorum sensing
The primary mechanism by which pneumococcal capsular polysaccharide-based vaccines are believed to mediate protection is by induction of serotype-specific opsonic antibodies that facilitate bacterial killing by phagocytes (opsonophagocytosis). However, antibodies that are protective against experim...
ORGANISM(S): Streptococcus pneumoniae 
2011-03-01 | E-GEOD-27258 | biostudies-arrayexpress
ProteomicsWho’s bad? – Impact of pneumococcal and viral pneumonia on the respiratory and intestinal tract microbiome of mice
With annually 2.56 million deaths worldwide, pneumonia is one of the leading causes of death. Most frequent causative pathogens are Streptococcus pneumoniae and influenza A virus. Lately, the interaction between pathogens, the host and its microbiome gained more attention. A healthy microbiome is kn...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-24 | PXD036014 | Pride
Influenza Multi-omics Streptococcus pneumoniae Pneumonia Mice Microbiome 
ProteomicsImpact of pneumococcal and viral pneumonia on the respiratory and intestinal tract microbiome of mice part II
With annually 2.56 million deaths worldwide, pneumonia is one of the leading causes of death. Most frequent causative pathogens are Streptococcus pneumoniae and influenza A virus. Lately, the interaction between pathogens, the host and its microbiome gained more attention. A healthy microbiome is kn...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-24 | PXD036279 | Pride
Influenza Multi-omics Streptococcus pneumoniae Pneumonia Mice Microbiome 
ProteomicsWho’s bad? – Impact of pneumococcal and viral pneumonia on the respiratory and intestinal tract microbiome of mice
With annually 2.56 million deaths worldwide, pneumonia is one of the leading causes of death. Most frequent causative pathogens are Streptococcus pneumoniae and influenza A virus. Lately, the interaction between pathogens, the host and its microbiome gained more attention. A healthy microbiome is kn...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-24 | PXD036115 | Pride
Influenza Multi-omics Streptococcus pneumoniae Pneumonia Mice Microbiome 
ProteomicsWho’s bad? – Impact of pneumococcal and viral pneumonia on the respiratory and intestinal tract microbiome of mice
With annually 2.56 million deaths worldwide, pneumonia is one of the leading causes of death. Most frequent causative pathogens are Streptococcus pneumoniae and influenza A virus. Lately, the interaction between pathogens, the host and its microbiome gained more attention. A healthy microbiome is kn...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-24 | PXD036129 | Pride
Influenza Multi-omics Streptococcus pneumoniae Pneumonia Mice Microbiome 
MetabolomicsAirway metabolic profiling during Streptococcus pneumoniae infection identifies branched chain amino acids as signatures of upper airway colonisation

Streptococcus pneumoniae is a leading cause of community-acquired pneumonia and bacteraemia and is capable of remarkable phenotypic plasticity, responding rapidly to environmental change. Pneumococcus is a nasopharyngeal commensal, but is responsible for severe, acute infections followin...

2023-08-08 | MTBLS4591 | MetaboLights
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