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TranscriptomicsImmune Responses to Pneumocystis Infection are Robust in Immunocompetent Mice but Absent in CD40 Ligand Deficient Mice
Pneumocystis is a pathogen of immunocompromised hosts but can also infect healthy hosts, in whom infection is rapidly controlled and cleared. To better understand the immune mechanisms contributing to clearance of infection, microarray methods were used to examine differential gene expression in the...
ORGANISM(S): Mus musculus 
2008-12-22 | E-GEOD-11005 | biostudies-arrayexpress
TranscriptomicsType I IFN-signaling following Pneumocystis (PC)-infection and clearance in CD4 T cell-competent mice
Type I IFN-signaling suppresses an excessive IFN-{gamma} response and prevents lung damage and chronic inflammation following Pneumocystis (PC)-infection and clearance in CD4 T cell-competent mice. Type I IFN -signaling in pulmonary CD11c+ DCs and alveolar macrophages may prevent chronic inflammatio...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-18607 | biostudies-arrayexpress
TranscriptomicsMicroarray studies on effect of Pneumocystis carinii infection on global gene expression in alveolar macrophages
With a filter of false-discovery rate less than 0.1 and fold change greater than 1.5, 115 genes were found to be up- and 137 were down-regulated in alveolar macrophages during Pneumocystis carinii infection. Total RNA samples from 4 each of normal, dexamethasone-treated, and Pneumocystis carinii-inf...
ORGANISM(S): Rattus norvegicus 
2010-04-12 | E-GEOD-20149 | biostudies-arrayexpress
ProteomicsProteomic Profiling and Functional Analysis of B Cell-Derived Exosomes upon Pneumocystis Infection
Pneumocystis is a life-threatening fungal pathogen frequently causing fatal pneumonia (PCP) in immunocompromised individuals with high mortality. Recently, B cells have been reported to play a crucial role in the pathogenesis of PCP through producing antibodies and activating CD4+ T cell response. E...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-26 | PXD030103 | Pride
Exosomes Mass spectrometry B lymphocytes Pneumocystis pneumonia 
GenomicsPneumocystis jirovecii TSA
Transcriptome of Pneumocystis jirovecii during human Pneumocystis pneumonia
PRJEB370 | ENA
GenomicsPneumocystis carinii pneumonia Diagnosis via Metagenomic Next-Generation Sequencing
Pneumocystis carinii pneumonia Diagnosis via Metagenomic Next-Generation Sequencing
PRJEB43652 | ENA
GenomicsPneumocystis jirovecii
Pathogenic fungus that causes pneumonia in immunocompromised persons
PRJNA20531 | ENA
TranscriptomicsPrevention of bone marrow cell apoptosis and regulation of hematopoiesis by type I IFNs during systemic responses to pneumocystis (PC) lung infection
IFrag-/- but not RAG-/- mice develop rapidly progressing bone marrow failure in response to PC lung infection. Changes contributing to accelerated bone marrow cell apoptosis in IFrag-/- mice appear to be initiated around day 7 post infection. To gain further insight into the mechanism underlying the...
ORGANISM(S): Mus musculus 
2012-02-20 | E-GEOD-27835 | biostudies-arrayexpress
TranscriptomicsTotal lung gene expression data of Pneumocystis-infected wildtype and IFN-gamma knockout mice.
Pulmonary hypertension (PH) is a disease of diverse etiology. While primary PH can develop in the absence of prior disease, PH more commonly develops in conjunction with other pulmonary pathologies. We previously reported a mouse model in which PH occurs as a sequelae of Pneumocystis infection in th...
ORGANISM(S): Mus musculus 
2013-10-27 | E-GEOD-51750 | biostudies-arrayexpress
TranscriptomicsCRISPR-mediated detection of Pneumocystis transcripts in bronchoalveolar, oropharyngeal, and serum specimens for Pneumocystis pneumonia diagnosis
Background. Pneumocystis jirovecii pneumonia (PCP) is a leading cause of fungal pneumonia, but its diagnosis primarily relies on invasive bronchoalveolar lavage (BAL) specimens that are difficult to obtain. Oropharyngeal swabs and serum could improve the PCP diagnostic workflow, and we hypothesized ...
ORGANISM(S): Homo sapiens Pneumocystis jirovecii RU7 
2025-03-17 | GSE289324 | GEO
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