Podocyte injury

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Impaired Glycolysis-Derived Serine Metabolism as a Key Driver of Podocyte Injury with Senescence

Chronic kidney disease (CKD) is a major health issue, with podocyte injury with senescence playing a central role in glomerulosclerosis. This study investigates the link between glycolysis-derived serine metabolism and podocyte injury with senescence, focusing on the role of phosphoglycerate kina...

2025-08-23 | MTBLS12883 | MetaboLights

Indoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand, mediates progressive glomerular disease by damaging podocytes

Indoxyl sulfate (IS) is a uremic toxin and ligand of the aryl-hydrocarbon receptor (Ahr), a transcriptional regulator. Elevated serum IS may contribute to the progression of kidney disease. Therefore, we assessed mouse podocyte damage mediated by IS. Ahr was predominantly localized to the podocyte n...

ORGANISM(S): Homo sapiens

2014-10-14 | E-GEOD-51834 | biostudies-arrayexpress

Comparison of Glomerular and Podocyte mRNA Profiles in eNOS-/- Diabetic Mice Induced by Streptozotocin

We compared mRNA profiles of isolated glomeruli versus sorted podocytes between diabetic and control mice. IRG mice crossed with eNOS-/- mice were further bred with podocin-rTTA and TetON-Cre mice to permanently label podocytes before the diabetic injury. Diabetes was induced by injection of strepto...

ORGANISM(S): Mus musculus

2016-03-16 | E-GEOD-79291 | biostudies-arrayexpress

IgM hyposialylation drives podocyte injury in pediatric and young adult patients with podocytopathies

Altered immunoglobulin glycosylation has been implicated in antibody-mediated podocytopathies, yet the functional impact of IgM sialylation remains unclear. Previous evidence suggested that circulating cationic or hyposialylated IgM may contribute to podocyte injury in idiopathic nephrotic syndrome ...

ORGANISM(S): Homo sapiens (Human)

2026-06-29 | PXD070406 | Pride

Everolimus protects podocytes via stabilizing TUBB2B and DCDC2 expression

Glomerular podocytes are highly differentiated cells that are key components of the kidney filtration units. The podocyte cytoskeleton builds the basis for the dynamic podocyte cytoarchitecture and plays a central role for proper podocyte function. Recent studies implicate that immunosuppressive age...

ORGANISM(S): Homo sapiens

2015-09-09 | E-GEOD-66107 | biostudies-arrayexpress

Genome wide mapping of H3K27me3 in differentiated mouse podocytes

We explored H3K27me3 binding sites in the genome of differentiated, conditionally immortalized mouse podocytes. Cells were allowed to differentiate for 14 days, following thermoshifting, before treatment with either vehicle (DMSO) or the S-adenosylhomocysteine hydrolase inhibitor 3-deazaneplanocin ...

ORGANISM(S): Mus musculus

2015-12-09 | E-GEOD-69610 | biostudies-arrayexpress

Podocyte injury in Fabry nephropathy

Current therapies for Fabry disease are based on reversing intra-cellular accumulation of globotriaosylceramide (Gb3) by enzyme replacement (ERT) or chaperone mediated stabilization, thereby alleviating lysosome dysfunction. However, the therapeutic effect in the regression of end-organ damage (ie. ...

ORGANISM(S): Homo sapiens (Human)

2023-07-20 | PXD029618 | Pride

Nephropathy Crispr/cas9 Fabry disease podocyte

Podocyte injury in Fabry nephropathy

PRJNA773084 | ENA

Analysis of the podocyte proteome of LPS treated mice

Podocyte injury is a major cause of chronic kidney disease, but the involved signaling pathways are largely unknown. Here, we used ultrasensitive proteomics to investigate the response of native podocytes from mice with Doxorubicin-induced injury. We observed perturbations of known propagating pathw...

ORGANISM(S): Mus musculus (Mouse)

2020-07-29 | PXD012064 | Pride

Fsgs podocyte Injury Kidney

SPARC Upregulation Mediates Podocyte Injury in Alport Syndrome Mice

PRJNA1336160 | ENA

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