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MetabolomicsMetabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor (Untargeted urine UPLC-MS assay)
BACKGROUND: Epidemiological evidence suggests a link between pesticide exposure and the development of metabolic diseases. However, most experimental studies have evaluated the metabolic effects of pesticides using individual molecules, often at non relevant doses or in combination with other r...
2019-05-28 | MTBLS596 | MetaboLights
TranscriptomicsEffects of low and high doses of bisphenol A on mouse liver transcriptome
Bisphenol A (BPA) is used in the plastic industry as the monomer of polycarbonates and epoxy resins. Heat and changes in pH conditions lead to its leakage from the plastics in which it is incorporated. This largely contributes to the widespread exposure of the general population to this environmenta...
ORGANISM(S): Mus musculus 
2011-09-20 | E-GEOD-26728 | biostudies-arrayexpress
TranscriptomicsGlobal hepatic gene expression data from PPARa liver KO, PPARa liver WT, PPARaKO and WT male mice fed ad libitum, fasted for 24 hours and re-fed
If the function of the nuclear receptor PPARa is well-known during a prolongated fasting, its hepatic biological function during feeding and refeeding conditions still needs to be investigated. Moreover, in vivo data collected so far on PPARa function during fasting were obtained using the total Ppa...
ORGANISM(S): Mus musculus 
2016-02-20 | E-GEOD-73299 | biostudies-arrayexpress
TranscriptomicsGlobal hepatic gene expression data from PPARa liver KO, PPARa liver WT, PPARaKO and WT male mice treated or not with Fenofibrate
Fenofibrate is a specific agonist of the nuclear receptor PPARa. To identify the gene expression under the strict dependence of hepatic PPARa activity, we generated a new mouse strain of PPARa-specific deletion in hepatocyte (albumin-Cre+/- Pparaflox/flox or LKO) and we compared them to total Ppara ...
ORGANISM(S): Mus musculus 
2016-02-20 | E-GEOD-73298 | biostudies-arrayexpress
TranscriptomicsHepatic transcriptome in wild-type and LXR-deficient mice
LXR is a transcription factor. Two isoforms exist in mice (alpha and beta). They are both expressed in the liver. We examined the role of LXR by obtaining gene expression profiles from the livers of wild-type and LXR-/- mice from the same genetic background. Liver gene expression was measured from m...
ORGANISM(S): Mus musculus 
2012-11-07 | E-GEOD-38083 | biostudies-arrayexpress
TranscriptomicsEffect of fipronil on the thyroid gland transcriptome in the rat
Fipronil is a widely-used broad-spectrum phenylpyrazole insecticide. It has been shown that fipronil increases the hepatic metabolism of thyroid hormone in the rat, which may induce compensatory mechanisms at the level of the thyroid gland itself. Here, we studied the effect of fipronil on the trans...
ORGANISM(S): Rattus norvegicus 
2016-09-07 | E-GEOD-75275 | biostudies-arrayexpress
UnknownFGF19 and its analog Aldafermin cooperate with MYC to induce aggressive hepatocarcinogenesis
Not available
S-SCDT-10_1038-S44321-023-00021-X | biostudies-other
UnknownHepatic FGF21 is not required for fasting metabolism but guides protein appetite post energy depletion
Not available
S-SCDT-10_1038-S44319-026-00790-9 | biostudies-other
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