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ProteomicsEffect of Kinase Inhibitors on Intraerythrocytic Plasmodium falciparum Phosphoproteome
Three flasks of asynchronous blood stage P. falciparum Dd2 culture were grown to ~15% parasitemia, 4% hematocrit using the Trager- Jensen method. Per biological replicate, parasites were treated with 5 x EC50 or EC90 of compound depending on the slope of the EC50 curve for 3 hours. Compounds are DC-...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Plasmodium Falciparum Dd2 (ncbitaxon:57267) 
2023-04-03 | MSV000091619 | MassIVE
GenomicsThreonine-4 of Mammalian RNA Polymerase II CTD is Targeted by Polo-like Kinase-3 and Required for Transcriptional Elongation
Eukaryotic RNA polymerase II (Pol II) has evolved an array of heptad repeats with the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 at the carboxy-terminal domain (CTD) of the large subunit (Rpb1). Differential phosphorylation of Ser2, Ser5, and Ser7 in the 5M-bM-^@M-^Y and 3M-bM-^@M-^Y regi...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-GEOD-37519 | biostudies-arrayexpress
GenomicsPolo-like kinase 1 inhibitors differentiate triple-negative breast cancer towards a luminal cell fate
Polo-like kinase 1 inhibitors differentiate triple-negative breast cancer towards a luminal cell fate
PRJNA763910 | ENA
ProteomicsMyotubularin-related proteins control abscission_StDenis_MTMR_P84_VS6-7-8-11-12
This submission is part of the mass spectrometry datasets for the manuscript by St-Denis et al. entitled: Myotubularin-related proteins 3 & 4 interact with PLK1 and CEP55 to control CEP55 recruitment to the midbody and ensure proper abscission. This submission contains 82 RAW files and 82 mgf files...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-10-30 | MSV000078915 | MassIVE
GenomicsBulk mitotic ATACseq for Polo-like kinase 1 maintains transcription and chromosomal accessibility during mitosis
Bulk mitotic ATACseq for Polo-like kinase 1 maintains transcription and chromosomal accessibility during mitosis
PRJNA1189003 | ENA
TranscriptomicsPDK1 Signaling Towards PLK1-Myc Activation Confers Oncogenic Transformation and Tumor Initiating Cell Activation and Resistance to mTOR-targeted Therapy.
Although 3-Phosphoinositide-dependent protein kinase-1 (PDK1) has been predominately linked to PI3K-AKT pathway, it may also evoke additional signaling outputs to promote tumorigenesis. Here we report that PDK1 directly induces phosphorylation of Polo-like kinase 1 (PLK1), which in turn induces Myc ...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-30669 | biostudies-arrayexpress
TranscriptomicsPolo-like kinase 1 inhibitors differentiate triple-negative breast cancer towards a luminal cell fate
Transcriptomic profiling was applied to investigate the effects of polo-like kinase 1 inhibition in triple-negative breast cancer.
ORGANISM(S): Homo sapiens 
2022-08-29 | GSE184295 | GEO
GenomicsPolo-like kinase inhibitors increase AAV production by halting cell cycle progression
Polo-like kinase inhibitors increase AAV production by halting cell cycle progression
PRJNA1142858 | ENA
GenomicsInhibition of aberrantly overexpressed Polo-like kinase 4 is a potential effective treatment for DNA damage repair-deficient uterine leiomyosarcoma
Polo-like kinase 4 inhibition in uterine leiomyosarcoma
PRJEB75545 | ENA
GenomicsActivation of polo-like kinase 1 correlates with selective motor neuron vulnerability in familial ALS
Activation of polo-like kinase 1 correlates with selective motor neuron vulnerability in familial ALS
PRJNA1138888 | ENA
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