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GenomicsRPB1 ChIP-Seq of NSC from Wild Type (WT) and Armc5 knockout mice
ARMC5 is a protein containing an armadillo domain (ARM) and a BTB domain. Its gene knockout caused many phenotypes, including dwarfism, compromise T-cell immunity, and adrenal gland hypertrophy. ARMC5 mutation in humans is associated with bilateral macronodular adrenal gland hypertrophy. We found th...
ORGANISM(S): Mus musculus 
2023-12-01 | GSE169582 | GEO
TranscriptomicsRNA-Seq of neural stem cells from Wild Type (WT) and Armc5 knockout mice
ARMC5 is a protein containing an armadillo domain (ARM) and a BTB domain. Its gene knockout caused many phenotypes, including dwarfism, compromise T-cell immunity, and adrenal gland hypertrophy. ARMC5 mutation in humans is associated with bilateral macronodular adrenal gland hypertrophy. We found th...
ORGANISM(S): Mus musculus 
2023-12-01 | GSE169350 | GEO
GenomicsRPB1 ChIP-Seq of NSC from Wild Type (WT) and Armc5 knockout mice
RPB1 ChIP-Seq of NSC from Wild Type (WT) and Armc5 knockout mice
PRJNA717040 | ENA
GenomicsRNA-Seq of neural stem cells from Wild Type (WT) and Armc5 knockout mice
RNA-Seq of neural stem cells from Wild Type (WT) and Armc5 knockout mice
PRJNA716311 | ENA
UnknownARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans.
Not available
S-EPMC10789052 | biostudies-literature
ProteomicsARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans
ARMC5 is an armadillo domain (ARM)-containing protein. We found that Armc5 KO mice had an increased incidence of neural tube defects (NTDs). ARMC5 is the substrate recognition component of a ubiquitin ligase that targets POLR2A, the largest subunit of RNA polymerase II (Pol II). Surprisingly, the ab...
ORGANISM(S): Homo sapiens (Human) 
2023-12-06 | PXD047572 | Pride
Myelomeningocele Armc5 Pol ii pool size Folh1 12 subunits of pol ii Polr2a-specific e3 Ubiquitin ligase Cullin 3 Neural tube defects 
ProteomicsARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans
ARMC5 is an armadillo domain (ARM)-containing protein. We found that Armc5 KO mice had an increased incidence of neural tube defects (NTDs). ARMC5 is the substrate recognition component of a ubiquitin ligase that targets POLR2A, the largest subunit of RNA polymerase II (Pol II). Surprisingly, the ab...
ORGANISM(S): Homo sapiens (Human) 
2023-12-06 | PXD047533 | Pride
Myelomeningocele Armc5 Pol ii pool size Folh1 12 subunits of pol ii Polr2a-specific e3 Ubiquitin ligase Cullin 3 Neural tube defects 
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