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MetabolomicsSearching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells
Non-small cell lung cancer (NSCLC) is the most lethal and prevalent type of lung cancer. In almost all types of cancer, the levels of polyamines (putrescine, spermidine, and spermine) are increased, playing a pivotal role in tumor proliferation. Indomethacin, a non-steroidal anti-inflammatory drug, ...
2021-02-08 | MTBLS873 | MetaboLights
MetabolomicsOA-HOXB9-ODC1-Polyamine Axis Mediates Metabolic Syndrome Promoting Endometrial Cancer Progression

Metabolic syndrome (MS) is a risk factor for both the development and progression of endometrial cancer (EC); however, the mechanism remains unclear. We found that polyamine metabolites are significantly elevated in the sera and tumor tissues of EC patients with MS (ECWMS). Hyperlipidemia is a cr...

2025-11-08 | MTBLS13106 | MetaboLights
TranscriptomicsTemporal transcriptional profiling of polyamine-depleted NIH3T3 cells
Polyamines are absolutely required for cell growth and proliferation. While polyamine depletion results in reversible cell cycle arrest, the actual mechanism of growth inhibition is still obscure. This work aimed at determining the cellular processes affected by reduction in the intracellular polyam...
ORGANISM(S): Mus musculus 
2012-09-11 | E-GEOD-36445 | biostudies-arrayexpress
TranscriptomicsPerturbation of polyamine catabolism affects normal grape ripening of Trincadeira cultivar
Grapes (Vitis vinifera L.) are economically the most important fruit crop worldwide. However, the complexity of molecular and biochemical events that lead to ripening of nonclimacteric fruits is not fully understood. In particular the role of polyaminesM-BM-4 catabolism has been little explored. Ri...
ORGANISM(S): Vitis vinifera 
2013-09-30 | E-GEOD-44823 | biostudies-arrayexpress
TranscriptomicsTemporal transcriptional profiling of growth resumption following polyamine-depletion
Polyamines are absolutely required for cell growth and proliferation. While polyamine depletion results in reversible cell cycle arrest, the actual mechanism of growth inhibition is still obscure. This experiment aimed at determining the cellular processes elicited by re-addition of polyamines to po...
ORGANISM(S): Mus musculus 
2012-09-11 | E-GEOD-36664 | biostudies-arrayexpress
GenomicsDual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas
Diffuse intrinsic pontine glioma (DIPG) is an incurable malignant childhood brain tumour, with no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small organic polycations that are essential for DNA replication, translation and cell proliferation. Ornithine decarboxyl...
EGAS00001004905 | EGA
ProteomicsATP13A3 is a major component of the enigmatic mammalian polyamine transport system
Polyamines, including putrescine (PUT), spermidine (SPD) and spermine (SPM), are abundant polycations supporting various cellular functions. Their cellular content is tightly controlled by biosynthesis, degradation and uptake or export via the polyamine transport system (PTS). However, the mammalian...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2020-12-09 | PXD020559 | Pride
Polyamines Putrescine Q exactive hf Atp13a3 P5b-atpase Cho cells Polyamine transport system 
MetabolomicsBacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

The reverse transsulfuration pathway is the major route for the metabolism of sulfur-containing amino acids. The role of this metabolic pathway in macrophage response and function is unknown. We show that the enzyme cystathionine γ-lyase (CTH) is induced in macrophages infected with pathogenic ba...

2020-05-15 | MTBLS696 | MetaboLights
TranscriptomicsPlasmodium falciparum treated with cyclohexylamine
Transcriptional profiling of P. falciparum cultures treated with cyclohexylamine over time (18, 25 and 30 hours post invasion) A control experiment was also set up in which P. falciparum was not treated with cyclohexylamine, and samples were taken at 18, 25 and 30 h post invasion). Background Plasm...
ORGANISM(S): Plasmodium falciparum 
2010-04-19 | E-GEOD-18075 | biostudies-arrayexpress
UnknownExploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase.
Not available
S-EPMC6407594 | biostudies-literature
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