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MetabolomicsSAR11 Cells Rely on Enzyme Multifunctionality to Transport and Metabolize a Range of Polyamine Compounds
In the ocean surface layer and cell culture, the polyamine transport protein PotD of SAR11 bacteria is often one of the most abundant proteins detected. Polyamines are organic cations at seawater pH produced by all living organisms and are thought to be an important component of dissolved organic ma...
2021-09-09 | MTBLS3146 | MetaboLights
MetabolomicsAftpo3 and Afdur3, the Aspergillus fumigatus Plasma Membrane Transporters of Polyamines, Regulate Polyamine Homeostasis and Itraconazole Susceptibility

Aspergillus fumigatus is a notorious opportunistic pathogen that causes Invasive Aspergillosis (IA) infections with high mortality in immunosuppressed individuals. Long-term antifungal drug azole abuse in clinical treatment and agriculture renders it ineffectual or drug resistant. Drug resistance...

2020-12-21 | MTBLS1739 | MetaboLights
ProteomicsATP13A3 is a major component of the enigmatic mammalian polyamine transport system
Polyamines, including putrescine (PUT), spermidine (SPD) and spermine (SPM), are abundant polycations supporting various cellular functions. Their cellular content is tightly controlled by biosynthesis, degradation and uptake or export via the polyamine transport system (PTS). However, the mammalian...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2020-12-09 | PXD020559 | Pride
Polyamines Putrescine Q exactive hf Atp13a3 P5b-atpase Cho cells Polyamine transport system 
MetabolomicsSIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux
Mitochondrial function relies on the coordinated transcription of mitochondrial and nuclear genomes to assemble respiratory chain complexes. Across species, the SIN3 coregulator influences mitochondrial functions, but how its loss impacts mitochondrial homeostasis and metabolism in the context of a ...
2024-04-01 | MTBLS8439 | MetaboLights
TranscriptomicsPerturbation of polyamine catabolism affects normal grape ripening of Trincadeira cultivar
Grapes (Vitis vinifera L.) are economically the most important fruit crop worldwide. However, the complexity of molecular and biochemical events that lead to ripening of nonclimacteric fruits is not fully understood. In particular the role of polyaminesM-BM-4 catabolism has been little explored. Ri...
ORGANISM(S): Vitis vinifera 
2013-09-30 | E-GEOD-44823 | biostudies-arrayexpress
UnknownATP13A3 is a major component of the enigmatic mammalian polyamine transport system.
Not available
S-EPMC7948421 | biostudies-literature
UnknownATP13A4 Upregulation Drives the Elevated Polyamine Transport System in the Breast Cancer Cell Line MCF7.
Not available
S-EPMC10296708 | biostudies-literature
UnknownNovel Green Fluorescent Polyamines to Analyze ATP13A2 and ATP13A3 Activity in the Mammalian Polyamine Transport System.
Not available
S-EPMC9953717 | biostudies-literature
UnknownThe Effect of Impaired Polyamine Transport on Pneumococcal Transcriptome.
Not available
S-EPMC8540371 | biostudies-literature
UnknownATP13A3 facilitates polyamine transport in human pancreatic cancer cells.
Not available
S-EPMC8904813 | biostudies-literature
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