Polyglutamine - OmicsDI

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Mus musculus (86)
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UNIPROT ID/AC

P42858 (1)
P37840 (1)

Metabolite Name

2H-benzo[d]1,3-dioxolan-5-yl-N-(4,5-dimethyl(1,3-thiazol-2-yl))carboxamide (2)
Spectral Match to Val-Phe from NIST14 (2)
Polyglutamine (2)
3-(beta-D-Glucopyranosyloxy)-7-(alpha-L-rhamnopyranosyloxy)-5-hydroxy-4'-methoxyflavone (2)
4-methylquinoline-2-carboxylic acid (2)
(R)-alpha-Methylhistamine (2)
Methylene-imidazole (2)
1H-Imidazole-4-propanol, beta-amino-, (S)- (2)
Spectral Match to Ile-Leu from NIST14 (2)
3-oxo-Butanal (2)
Phenylalanine methyl ester (2)
Spectral Match to Val-Ile from NIST14 (2)
Leucyl-alanine (2)
Polyalanine (2)
Dihydrocorticosterone (2)
Benzothiazolone (2)
Tri(2-butoxyethyl) phosphate (2)
(7R)-7-[(Dodeca-4,7,10-trienoyl)oxy]-4-hydroxy-N,N,N-trimethyl-4-oxo-3,5,9-trioxa-4lambda~5~-phosphapentacosan-1-aminium (2)
2-(2-amino-3-phenylpropanamido)-3-methylbutanoic acid (2)
Spectral Match to Ile-Met from NIST14 (2)
1-Stearoyl-2-linoleoylphosphatidylcholine (2)
4-oxo-Butanal (2)
Spectral Match to Ser-Phe from NIST14 (2)
2-(2-aminopropanamido)-4-methylpentanoic acid (2)
6-oxo-Butanal (2)
3-(Dodecanoylamino)propyl(carboxymethyl)dimethylammonium (2)
Prostaglandin F28a (2)
Indole-3-carbaldehyde (2)
L-Acetylleucine (2)
Capric dimethyl amine oxide (2)

First Public Date

2014 (32)
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Modelling Approach

Ordinary differential equation model (2)

Study status

Recruiting (1)

Lab affiliation

1The Rappaport Faculty of Medicine and Research Institute, Haifa 3109601, Israel; 2Network Biology Research Laboratories, Technion-Israel Institute of Technology, Haifa 3200003, Israel (2)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands (2)
Zbynek Zdrahal, Research group Proteomics, CEITEC-MU, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic (1)
Professor Cellular Imaging, Huntington degradation research groupleader Department of Medical Biology, Amsterdam UMC (AMC), Meibergdreef 15, 1105AZ Amsterdam, the Netherlands (1)
Department of Physiology, Department of Neurobiology, University of California Los Angeles. Los Angeles, CA 90095-1751, USA (1)
Professor Cellular Imaging, PI Huntington degradation research groupleader, Department of Medical Biology, Amsterdam UMC location AMC, Amsterdam, The Netherlands (1)
Structural Genomics Consortium, University of Toronto, Toronto ON M5G 1L7, Canada. Tel.: 416-946-0881 E-mail: cheryl.arrowsmith@uhnresearch.ca (1)
Goethe University Frankfurt, University Hospital, Clinic of Neurology, Experimental Neurology, Heinrich- Hoffmann-Str. 7, 60528 Frankfurt am Main, Germany (1)
Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82159 Martinsried, Germany (1)
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, US (1)
Department of Molecular Biology, Princeton University, Princeton NJ, USA (1)
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Dept of Biochemistry, Medical Sciences Building, Schulich School of Medicince and Dentistry, University of Western Ontario, London, ON, Canada (1)
Department of Psychiatry and Human Behavior University of California Irvine 4056 Gross Hall/ Stem Cell Research Center 845 Health Sciences Road Irvine, CA 92697-1705 (1)
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD (1)
Interfaculty Institute of Biochemistry Universität Tübingen Hoppe-Seyler Straße 4 72076 Tübingen Germany (1)
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Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany Department of Proteomics and Signal Transduction (1)
Experimental Neurology, University Hospital, Frankfurt am Main, Germany (1)
Max Planck Institute for Biology of Ageing, Joseph Stelzmann Strasse 9b, 50931 Cologne, Germany Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50674 Cologne, Germany (1)
University of Cologne, Germany (1)
Department of Biology, Cellular Proteostasis and Mass Sepectrometry, University of Konstanz (1)
NHMRC Senior Research Fellow Department of Biochemistry and Molecular Biology | Faculty of Medicine, Dentistry and Health Sciences Level 2 South, Bio21 Molecular Science and Biotechnology Institute, 30 Flemington Road The University of Melbourne, Victoria 3010 Australia (1)
CECAD Forschungszentrum, Joseph-Stelzmann-Str. 26, 50931 Köln (1)
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Motor Neuron Disease Research Centre, Macquarie University, Macquarie Park NSW 2109 Australia (1)
Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia (1)
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Intestinal Bromhidrosis Syndrome (1)
Autosomal recessive extra oral halitosis (1)
CACNA1H mutation (1)
Dimethylglycine dehydrogenase deficiency (1)

IsPrivate

False (2)

Study type

Transcription profiling by array (47)
ChIP-seq (5)
RNA-seq of coding RNA (5)
Animal - One-color microarray (2)
Methylation profiling by high throughput sequencing (2)
Observational patient registry (1)

Release Date

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Location

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Histone deacetylation-dependent and -independent transcriptional dysregulation in early-onset polyglutamine disease

Transcriptional dysregulation is an important early feature of polyglutamine diseases. One of its proposed causes is defective neuronal histone acetylation, but important aspects of this hypothesis, such as the precise genomic topography of acetylation deficits and the relationship between transcrip...

ORGANISM(S): Mus musculus

2013-06-20 | E-GEOD-44854 | biostudies-arrayexpress

Effect of polyglutamine expanded TBP on microRNA expression in Neuro2A cells

The study was carried out to identify changes in expression of microRNAs in Neuro2A cells transfected with TATA binding protein (TBP) containing a polyglutamine expansion (59 glutamine-59Q) compared to normal TBP. Neuro2A cells were transfected in triplicate with either 16Q-TBP-GFP fusion or 59Q TBP...

ORGANISM(S): Mus musculus

2012-07-09 | E-GEOD-25592 | biostudies-arrayexpress

Functional sequestration of MOAG-2/LIR-3 by polyglutamine expansion proteins

PRJEB12258 | ENA

DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation

PRJNA1211158 | ENA

Polyglutamine Atrophin provokes neurodegeneration in Drosophila

Dentatorubral-pallidoluysian Atrophy (DRPLA) is a human polyQ disease caused by the expansion of a CAG strech in the atrophin-1 (at-1) gene. In all vertebrates, a second atrophin gene (at-2) is present and it encodes a related protein void of polyQ tracks. In D.melanogaster there is one conserved At...

ORGANISM(S): Drosophila melanogaster

2011-03-01 | E-GEOD-26246 | biostudies-arrayexpress

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

Huntington’s disease results from expansion of a glutamine-coding CAG tract in the huntingtin (HTT) gene, producing an aberrantly functioning form of HTT. Both wildtype and disease-state HTT form a hetero-dimer with HAP40 of unknown functional relevance. We demonstrate in vivo and in cell models tha...

ORGANISM(S): Homo sapiens (Human)

2022-09-09 | PXD028415 | Pride

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

ORGANISM(S): Homo sapiens (Human)

2022-02-21 | PXD028313 | Pride

Saxs Huntingtin Xl-ms Cryo-em Integrative modeling

Polyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1

This SuperSeries is composed of the following subset Series: GSE38000: Polyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (ChIP-Seq) GSE38001: Polyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (mRNA) Refer to individual Series

ORGANISM(S): Mus musculus

2012-06-18 | E-GEOD-38002 | biostudies-arrayexpress

Novel polyglutamine model uncouples proteotoxicity from aging.

Not available

S-EPMC4016013 | biostudies-literature

Pseudouridine-dependent ribosome biogenesis selectively regulates translation of polyglutamine proteins during Drosophila oogenesis [pulldown]

PRJNA851777 | ENA

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