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MetabolomicsUCP2-dependent redox-sensing in POMC neurons regulates feeding
Not available
ORGANISM(S): Mus musculus 
ST002361 | MetabolomicsWorkbench
TranscriptomicsIdentification of the hypothalamic neuronal populations that derive from Pomc-expressing precursors
Hypothalamic neuronal populations are central regulators of energy homeostasis and reproductive function. However, the ontogeny of these critical hypothalamic neuronal populations is largely unknown. Here, we reveal novel cellular fates of the hypothalamic Pomc-expressing precursors by combining mou...
ORGANISM(S): Mus musculus 
2015-04-16 | E-GEOD-56917 | biostudies-arrayexpress
ProteomicsFood perception liver phosphoproteome induced by caged food and POMC neuron activation
Liver mitochondria play a central role in metabolic adaptations to changing nutritional states, yet their dynamic regulation upon anticipated changes in energy state has remained unaddressed. Here, we show that sensory food perception rapidly induces mitochondrial fission in the liver via protein ki...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-28 | PXD044227 | Pride
Pomc Food perception Liver Lc-ms/ms 
MetabolomicsHypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue

The central nervous system has been implicated in the age-induced reduction in adipose tissue lipolysis. SLC7A14 is a lysosomal membrane protein highly expressed in the brain. Herein, we investigated the possible role of hypothalamic SLC7A14 in the age-induced lipolysis reduction. In this study, ...

2024-07-23 | MTBLS9872 | MetaboLights
TranscriptomicsRNAseq of mouse POMC neurons
From the arcuate nucleus of mice, we have dissociated neurons that express Proopiomelanocortin(POMC) and captured them on the Fluidigm C1 platform. These neuronsplay important roles in the regulation of appetite and sexual behavior. Here we propose tosequence RNA from 96 single POMC-expressing neuro...
ORGANISM(S): Mus musculus 
2015-04-28 | E-ERAD-357 | biostudies-arrayexpress
GenomicsGlycogen Metabolism Drives Sensory Activation of Pomc Neurons
Glycogen Metabolism Drives Sensory Activation of Pomc Neurons
PRJNA930442 | ENA
GenomicsEphrinB1 Modulates Glutamatergic Inputs into POMC Neurons and Controls Glucose Homeostasis
EphrinB1 Modulates Glutamatergic Inputs into POMC Neurons and Controls Glucose Homeostasis
PRJNA605210 | ENA
GenomicsEGF activation of POMC gene transcription is mediated by STAT3
EGF activation of POMC gene transcription is mediated by STAT3
PRJNA1238353 | ENA
GenomicsPro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming
Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming
PRJNA559533 | ENA
TranscriptomicsDeletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to neurodegeneration and development of obesity
The activity of the endoribonuclease Dicer is crucial to produce the mature form of most microRNAs (miRNAs). Recent studies indicate that lack of miRNAs in different neuronal types results in a range of anatomical and behavioural phenotypes. In the present study we aimed to investigate the developme...
ORGANISM(S): Mus musculus 
2012-11-16 | E-GEOD-38672 | biostudies-arrayexpress
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