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TranscriptomicsNKL homeobox gene VENTX is part of a regulatory network in human conventional dendritic cells
Recently, we have documented a hematopoietic NKL-code mapping physiological expression patterns of NKL homeobox genes in human myelopoiesis including monocytes and their derived dendritic cells (DCs). Here, we enlarge this map to include normal NKL homeobox gene expressions in progenitor-derived DCs...
ORGANISM(S): Homo sapiens 
2021-12-01 | E-MTAB-10277 | biostudies-arrayexpress
TranscriptomicsRNA-seq of retinal organoids differentiated from hESCs carrying mutations in the RB1 gene
hESC lines carrying deleterious mutations in the RB1 gene in heterozygous and homozygous state were generated by genome-editing based on CRISPR/Cas9. Parental cell line and genome-edited cell lines were differentiated into retinal organoids for 152 days based on the Protocol published by Döpper et a...
ORGANISM(S): Homo sapiens 
2022-05-10 | E-MTAB-10331 | biostudies-arrayexpress
TranscriptomicsNKL homeobox genes NKX2-3 and NKX2-4 deregulate megakaryocytic-erythroid cell differentiation in AML
NKL homeobox genes encode transcription factors which impact normal development and hematopoietic malignancies if deregulated. Recently, we established a NKL-code which describes the physiological expression pattern of eleven NKL homeobox genes in the course of hematopoiesis, allowing evaluation of ...
ORGANISM(S): Homo sapiens 
2021-10-31 | E-MTAB-10941 | biostudies-arrayexpress
GenomicsAberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia
Our study illustrates the leukemic role of deregulated NKL homeobox genes HMX2 and HMX3 revealing molecular mechanisms of differentiation arrest in AML.Whole genome sequencing of EOL-1 identified two mutations in the regulatory upstream regions of HMX2/3 resulting in the generation of a novel ETS-si...
ORGANISM(S): Homo sapiens 
2020-09-23 | E-MTAB-9079 | biostudies-arrayexpress
TranscriptomicsMolecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression - RNA-seq
Retaining the mutational pattern of tumors, immortalized cell lines represent excellent tools for the molecular study of genetic aberrations. Tumors can consist of subclones which develop under selective forces driven by mutational alterations. This explains why after therapy, relapsed clones can be...
ORGANISM(S): Homo sapiens 
2021-12-02 | E-MTAB-11038 | biostudies-arrayexpress
TranscriptomicsMolecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression - WES
Retaining the mutational pattern of tumors, immortalized cell lines represent excellent tools for the molecular study of genetic aberrations. Tumors can consist of subclones which develop under selective forces driven by mutational alterations. This explains why after therapy, relapsed clones can be...
ORGANISM(S): Homo sapiens 
2021-12-02 | E-MTAB-11039 | biostudies-arrayexpress
GenomicsPRMT5 genomic deregulation supports growth and stress tolerance in chronic lymphocytic leukemia
Patients suffering from chronic lymphocytic leukemia (CLL) display highly diverse clinical courses ranging from indolent cases to aggressive disease with genetic and epigenetic features resembling this diversity. Here, we developed a comprehensive approach combining a variety of molecular and clinic...
ORGANISM(S): Homo sapiens 
2020-08-19 | E-MTAB-8203 | biostudies-arrayexpress
TranscriptomicsRegulatory T and T helper cells from BXD mouse strains
Parental and BXD mouse lines were received from Jackson Laboratory and The Oak Ridge National Laboratory. Splenocytes were isolated and stained with anti-CD4 and anti-CD25 antibodies. CD4+ T cells were separated into CD4+CD25+ Treg and CD4+CD25- Th cells. Tregs and Th cell were collected from splee...
ORGANISM(S): Mus musculus 
2011-12-15 | E-MTAB-836 | biostudies-arrayexpress
TranscriptomicsPRMT5 genomic deregulation supports growth and stress tolerance in chronic lymphocytic leukemia
Patients suffering from chronic lymphocytic leukemia (CLL) display highly diverse clinical courses ranging from indolent cases to aggressive disease with genetic and epigenetic features resembling this diversity. Here, we developed a comprehensive approach combining a variety of molecular and clinic...
ORGANISM(S): Homo sapiens 
2020-08-19 | E-MTAB-8219 | biostudies-arrayexpress
TranscriptomicsTime series of murine lungs after flu infection
Time course data from influenza A-infected mice were collected for up to 60 days after infection to monitor gene expression profiles of the host. Whole lungs of individual mice were harvested from three independent infection experiments and at least three biological replicates were taken for a singl...
ORGANISM(S): Mus musculus 
2012-06-30 | E-MTAB-764 | biostudies-arrayexpress
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