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TranscriptomicsTargeting MDM4/MDM2 binding interface for reactivation of p53 in cancer therapy
The aim of this experiment has been to investigate the transcriptional profile of HCT116 cells treated with Peptide-3 (Pep3) compared to untreated (NT), treated with solvent (DMSO) or with a mutated peptide (Pep3M) cells. Peptide-3 is a dodecapeptide able to interact with MDM2 at the levels of the i...
ORGANISM(S): Homo sapiens 
2017-04-18 | E-GEOD-62855 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human prostate cancer primary cultures
The histopathological and molecular heterogeneity of prostate cancer and the limited availability of human tumor tissue make unraveling the mechanisms of prostate carcinogenesis a challenging task. Our goal was to develop an ex vivo model that could be reliably utilized to define a prognostic signat...
ORGANISM(S): Homo sapiens 
2007-06-30 | E-GEOD-3868 | biostudies-arrayexpress
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