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TranscriptomicsGenome-wide analysis of gene expression perturbed by Pontin shRNA in MCF7 subjected to normoxic and hypoxic conditions
In order to investigate the role of Pontin methylation on the expression of hypoxia responsive genes across the whole genome, we performed a microarray analysis from RNAs isolated from MCF7 cells expressing either control shRNA (shNS) or Pontin shRNA(shPontin) in normoxic and hypoxic conditions. MCF...
ORGANISM(S): Homo sapiens 
2011-12-02 | E-GEOD-27813 | biostudies-arrayexpress
TranscriptomicsmRNA profiling of Pontin depleted ES cells and Oct4 depleted ES cells
In order to investigate the cooperative roles of Pontin and Oct4 for self-renewal and pluripotency in mouse ES cells, we performed mRNA-sequencing analysis from mRNAs isolated from Pontin- and Oct4-depleted ES cells. This analysis provides insight into molecular mechanisms for maintaining ES cell id...
ORGANISM(S): Mus musculus 
2015-10-16 | E-MTAB-1953 | biostudies-arrayexpress
TranscriptomicsPontin functions as an essential coactivator for Oct4 target genes and lincRNAs in embryonic stem cells.
The actions of transcription factors, chromatin modifiers, and noncoding RNAs are crucial for the programming of cellular states. Although chromatin remodeling factors regulate the functional status of cells including pluripotency and differentiation, how they cross-talk with embryonic stem (ES) ce...
ORGANISM(S): Mus musculus 
2015-04-08 | E-GEOD-58206 | biostudies-arrayexpress
TranscriptomicsExpression of foetal gene Pontin is essential in protecting heart against pathological remodelling and cardiomyopathy
Cardiac remodelling is a key process in the development of heart failure. Reactivation of foetal cardiac genes is often associated with cardiac remodelling, which might be the result of the activation of signalling pathways involved in heart failure. Here we studied the role of Pontin (Ruvbl1), whic...
ORGANISM(S): Mus musculus 
2025-01-14 | E-MTAB-14659 | biostudies-arrayexpress
OtherPontin Functions as A Transcriptional Co-activator for Retinoic Acid-induced HOX Gene Expression [GRO-seq]
Pontin is a AAA+ ATPase protein that has functions in various biological contexts including gene transcription regulation, chromatin remodeling, DNA damage sensing and repair, as well as assembly of protein and ribonucleoprotein complexes. Pontin is known to regulate the transcription of several imp...
ORGANISM(S): Homo sapiens 
2021-06-16 | GSE162371 | GEO
GenomicsPontin Functions as A Transcriptional Co-activator for Retinoic Acid-induced HOX Gene Expression [ChIP-seq]
Pontin is a AAA+ ATPase protein that has functions in various biological contexts including gene transcription regulation, chromatin remodeling, DNA damage sensing and repair, as well as assembly of protein and ribonucleoprotein complexes. Pontin is known to regulate the transcription of several imp...
ORGANISM(S): Homo sapiens 
2021-06-16 | GSE162360 | GEO
UnknownPontin Functions as A Transcriptional Co-activator for Retinoic Acid-induced HOX Gene Expression.
Not available
S-EPMC8184613 | biostudies-literature
GenomicsPontin Functions as A Transcriptional Co-activator for Retinoic Acid-induced HOX Gene Expression [ChIP-seq]
Pontin Functions as A Transcriptional Co-activator for Retinoic Acid-induced HOX Gene Expression [ChIP-seq]
PRJNA681598 | ENA
GenomicsPontin Functions as A Transcriptional Co-activator for Retinoic Acid-induced HOX Gene Expression [GRO-seq]
Pontin Functions as A Transcriptional Co-activator for Retinoic Acid-induced HOX Gene Expression [GRO-seq]
PRJNA681618 | ENA
UnknownHypoxia-induced methylation of a pontin chromatin remodeling factor.
Not available
S-EPMC3158161 | biostudies-literature
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