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Type 1 diabetes (T1D) is characterised by destruction of pancreatic beta cells by islet-infiltrating cytotoxic lymphocytes, and elevated intra-islet secretion of pro-inflammatory cytokines. We hypothesise that abnormal elevation of islet NAD, via activation of NAMPT, plays a key role in driving isle...
ORGANISM(S): Mus musculus 
Granulosa cells form highly specialized membrane connections with the oocyte and each other, allowing the passage of regulatory molecules and metabolites between cells. These connections must be maintained for oocyte growth in vitro and have been implicated in oocyte aging both in vivo and in vitro....
ORGANISM(S): Bos taurus 
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