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TranscriptomicsEpigenetic regulation during the pathologic process from human primary Sjögren’s syndrome to mucosa-associated lymphoid tissue lymphoma
Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by reduced activity of the exocrine glands (principally the salivary and lacrimal glands) due to chronic lymphocytic infiltration. pSS has been closely associated with an enhanced risk of mucosa-associated lymphoid tiss...
ORGANISM(S): Homo sapiens 
2021-04-17 | E-MTAB-10339 | biostudies-arrayexpress
TranscriptomicsRNAseq of 6 medulloblastoma cell lines
Medulloblastoma is subdivided into different subgroups: WNt, SHH, Group 3 and Group 4. Since these subgroups are associated with different OS and metastasis rates it is crucial to understand them better. Six medulloblastoma cell lines, DAOY, ONS-76, D458, HD-MB03, CHLA-01-MED, CHLA-01R-MED, have bee...
ORGANISM(S): Homo sapiens 
2022-03-02 | E-MTAB-9823 | biostudies-arrayexpress
GenomicsA unique role of Cohesin-SA1 in gene regulation and development [ChIP-Seq]
Vertebrates have two cohesin complexes that consist of Smc1, Smc3, Rad21/Scc1 and either SA1 or SA2, but their functional specificity is unclear. Mouse embryos lacking SA1 show developmental delay and die before birth. Comparison of the genome wide distribution of cohesin in wild-type and SA1-null c...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-32319 | biostudies-arrayexpress
TranscriptomicsA unique role of Cohesin-SA1 in gene regulation and development
This SuperSeries is composed of the following subset Series: GSE32234: A unique role of Cohesin-SA1 in gene regulation and development [Expression] GSE32319: A unique role of Cohesin-SA1 in gene regulation and development [Chip-Seq] Refer to individual Series
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-32320 | biostudies-arrayexpress
TranscriptomicsLeptin is Implicated in Aromatase Inhibitor Resistance in Breast Cancer Cells
Obesity represents a risk factor for breast cancer development and therapy resistance, but the molecular players underling these links are unclear. Here, we identify a role for the obesity-cytokine leptin in sustaining aromatase inhibitor (AI) resistant growth and progression in breast cancer. Using...
ORGANISM(S): Mus musculus 
2022-03-04 | E-MTAB-8843 | biostudies-arrayexpress
TranscriptomicsRNA-seq of two hybrid mouse embryonic stem cell lines in a competitive environment during pluripotency: comparison between separate and co-culture conditions
Compared two hybrid mouse embryonic stem cell lines (that contain the same nuclear background, but different mtDNA content) in separate and co-culture conditions. We investigated the genes differentially expressed between these two cell lines in separate and co-culture as well as the genes that chan...
ORGANISM(S): Mus musculus 
2020-01-18 | E-MTAB-8692 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis wild type and TROL (AT4G01050) knock-out plants
Here we describe TROL (thylakoid rhodanese-like protein), a nuclear-encoded component of thylakoid membranes that is required for sustaining efficient linear electron flow in vascular plants. Thus, TROL might represent a missing thylakoid membrane linker for the assembly of a ternary complex between...
ORGANISM(S): Arabidopsis thaliana 
2009-08-20 | E-MEXP-1783 | biostudies-arrayexpress
TranscriptomicsValidation of a genomics-based hypothetical adverse outcome pathway: 2,4-dinitrotoluene perturbs PPAR signaling impairing energy metabolism and decreasing exercise endurance
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-06-30 | E-GEOD-50170 | biostudies-arrayexpress
TranscriptomicsA Genome-wide Chronological Study of Gene Expression and Two Histone Modifications, H3K4me3 and H3K9ac, during Developmental Leaf Senescence [RNA-seq]
The genome-wide abundance of two histone modifications, H3K4me3 and H3K9ac, both associated with actively expressed genes, was monitored in Arabidopsis thaliana leaves at different time points during developmental senescence, along with expression in the form of RNA-seq data. H3K9ac and H3K4me3 mark...
ORGANISM(S): Arabidopsis thaliana 
2015-04-11 | E-GEOD-67777 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of R. subcapitata exposed to different concentrations of the zinc oxide nanoparticle NM-110 against untreated control groups
n the present study transcriptome analysis was employed to investigate the early molecular responses to exposure to the zinc oxide nanoparticle NM-110. R. subcapitata was exposed to the ZnO NP NM-110 according to OECD guidelines (OECD test No. 201). At the end of exposure time (72 hours), simultaneo...
ORGANISM(S): Raphidocelis subcapitata 
2026-04-15 | E-MTAB-16813 | biostudies-arrayexpress
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