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GenomicsMMSET alters EZH2 Binding in Myeloma Cells
We investigated EZH2 binding in the presence and absence of MMSET protein. MMSET overexpression in t(4;14)+ myeloma leads to global loss of H3K27 methylation and redistribution of EZH2 binding throughout the genome ChIP-seq for EZH2 in two cell types
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-57632 | biostudies-arrayexpress
GenomicsMMSET Induces Global and Focal Changes in Histone Methylation in Myeloma Cells
We investigated genome wide distribution of H3K36me2, H3K36me3 and H3K27me3 in the presence and absence of MMSET protein. MMSET overexpression in t(4;14)+ myeloma leads to global loss redistribution of H3K36me2 and genome-wide loss of H3K27 methylation. Despite the gloal decrease in H3K27me3, speci...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-57977 | biostudies-arrayexpress
TranscriptomicsTreatment of multiple myeloma cells with EZH2 small molecule inhibitor
We investigated differential gene expression in response to treatment of multiple myeloma cells with EZH2 inhibitor RNA-seq in two cell lines
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-57478 | biostudies-arrayexpress
TranscriptomicsMMSET regulation of gene expression in t(4;14)+ myeloma
We investigated gene expression in isogenic myeloma cell lines with or without overexpressed MMSET protein. MMSET is a histone methyltransferase which methylates lysine 36 on histone H3. Overexpression of MMSET in myeloma leads to a global increase in H3K36 methylation and concomitant decrease in H3...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-57863 | biostudies-arrayexpress
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