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GenomicsGenome-wide mapping of in vivo SCL/DNA interactions in erythroid cells
We have previously proposed two distinct molecular mechanisms by which SCL binds its targets in hematopoiesis; either by direct contact with specific DNA sequences or by indirect recruitment through interaction with other proteins. We have established that direct DNA binding is the major non-redund...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-18720 | biostudies-arrayexpress
TranscriptomicsGenome -wide identification of SCL's target genes in Megakaryocyte progenitors
Megakaryopoiesis is a complex process that involves major cellular changes and relies on controlled coordination of cellular proliferation and differentiation. These mechanisms are orchestrated in part by transcriptional regulators. The key hematopoietic transcription factor SCL/TAL1 is required for...
ORGANISM(S): Mus musculus 
2011-07-11 | E-GEOD-24969 | biostudies-arrayexpress
TranscriptomicsGenome-wide identification of SCL/Tal1‰€™s functional targets; insights into its mechanisms of action in primary erythroid cells
Coordination of cellular processes through the establishment of tissue-specific gene expression programmes is essential for lineage maturation. The basic helix-loop-helix haemopoietic transcriptional regulator SCL/Tal1 is required for terminal differentiation of red blood cells. To gain insight into...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21877 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human Acute Myeloid Leukemia samples
Not available
ORGANISM(S): Homo sapiens 
2011-01-21 | E-TABM-978 | biostudies-arrayexpress
TranscriptomicsFunctional and genetic heterogeneity of distinctive leukaemic stem cell populations in CD34- human Acute Myeloid Leukaemia
We performed RNA-sequencing of normal haematopoietic stem cells and progenitor populations and of Leukemic Stem Cells in CD34- Acute Myeloid Leukaemia.
ORGANISM(S): Homo sapiens 
2016-06-22 | E-MTAB-2672 | biostudies-arrayexpress
TranscriptomicsFunctional and transcriptional heterogeneity of human hemopoietic lympho-myeloid progenitors
Cord blood (CB) samples from normal donors were obtained with informed consent. Fresh CB samples were processed within 18-34h after collection. Mononuclear cells were isolated and CD34+ fraction was separated. CB CD34+ enriched fraction was lineage depleted by staining with purified anti-human CD2, ...
ORGANISM(S): Homo sapiens 
2017-10-03 | E-MTAB-5456 | biostudies-arrayexpress
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