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TranscriptomicsTranscription profiling of superior mesenteric arteries from rats that have had portal vein ligation or a sham procedure for different lengths of time
Twenty-four male Sprague-Dawley rats were used for this experiment, a partial portal vein ligadure (PVL) was carried out in 12 rats, the other 12 rats were sham-operated. Superior mesenteric artery (SMA) samples were sequentially obtained from 2 rats from the PVL and sham groups at 1, 6, and 24 hour...
ORGANISM(S): Rattus norvegicus 
2008-05-09 | E-MEXP-1107 | biostudies-arrayexpress
ProteomicsProteomic profile in the diagnostics of portal hypertension in patients with compensated advanced liver disease
Study aim: To compare proteomic profiles of patients with compensated advanced liver disease with and without clinically significant portal hypertension (CSPH) and by analyzing differently expressed proteins to identify potential new serum biomarkers for the early diagnosis of CSPH. Subjects and met...
ORGANISM(S): Homo sapiens (Human) 
2024-02-01 | PXD040807 | Pride
Proteomics Biological markers Liver cirrhosis Portal hypertension 
TranscriptomicsTranscriptomic signatures of progressive and regressive liver fibrosis and portal hypertension
Persistent liver injury triggers a fibrogenic program that causes pathologic remodelling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension. The dynamics of gene regulation during liver disease progression and regression remain understudied. Here, we generated hepatic tra...
ORGANISM(S): Mus musculus 
2024-02-13 | E-MTAB-13804 | biostudies-arrayexpress
TranscriptomicsExpression data from patients of idiopathic portal hypertension
Idiopathic portal hypertension (IPH) is characterized by portal hypertension due to obstruction or stenosis of the intrahepatic peripheral portal branches. Researchers have suggested that IPH may be attributed to intrahepatic peripheral portal vein thrombosis, splenic factors, abnormal autoimmunity,...
ORGANISM(S): Homo sapiens 
2015-06-06 | E-GEOD-69601 | biostudies-arrayexpress
GenomicsPortal Hypertension Induced Changes in Splenic Gene Expression
Portal Hypertension Induced Changes in Splenic Gene Expression
PRJNA453393 | ENA
GenomicsPortal Hypertension Induced Changes in Splenic microRNA Expression
Portal Hypertension Induced Changes in Splenic microRNA Expression
PRJNA453394 | ENA
GenomicsTranscriptomic signatures of progressive and regressive liver fibrosis and portal hypertension
Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension
PRJEB72640 | ENA
GenomicsTranscriptomic signatures of progressive and regressive liver fibrosis and portal hypertension
Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension
PRJEB63606 | ENA
GenomicsGIMAP5 maintains liver sinusoidal endothelial cell identity and prevents portal hypertension
GIMAP5 maintains liver sinusoidal endothelial cell identity and prevents portal hypertension
PRJNA667260 | ENA
TranscriptomicsPortal Hypertension Induced Changes in Splenic Gene Expression
Splenomegaly is caused by several pathological conditions, including portal hypertension, which is most frequently caused by chronic liver disease (e.g., liver cirrhosis). The detailed mechanisms through which portal pressure induces splenomegaly and the precise pathophysiological conditions in port...
ORGANISM(S): Rattus norvegicus 
2018-11-21 | GSE113613 | GEO
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