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ProteomicsKAT5-mediated acetylation of PC4 facilitates DNA repair by promoting chromatin reorganization
Human positive coactivator 4 (PC4), is a highly abundant non-histone chromatin protein involved in diverse cellular processes, including transcription regulation, genome organization, autophagy, B-cell differentiation, neurogenesis, DNA repair, etc. Most PC4 is phosphorylated in cells, which interac...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD059878 | Pride
Non-histone chromatin protein Lysine acetyltransferases (kats) Positive coactivator 4 (pc4) Dna damage Atomic force microscopy (afm) 
ProteomicsKAT5-mediated acetylation of PC4 facilitates DNA repair by promoting chromatin reorganization
Human positive coactivator 4 (PC4), is a highly abundant non-histone chromatin protein involved in diverse cellular processes, including transcription regulation, genome organization, autophagy, B-cell differentiation, neurogenesis, DNA repair, etc. Most PC4 is phosphorylated in cells, which interac...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD058855 | Pride
Non-histone chromatin protein Lysine acetyltransferases (kats) Positive coactivator 4 (pc4) Dna damage Atomic force microscopy (afm) 
UnknownPositive coactivator PC4 shows dynamic nucleolar distribution required for rDNA transcription and protein synthesis.
Not available
S-EPMC12167574 | biostudies-literature
UnknownThe Catalytic Subunit of Schizosaccharomyces pombe CK2 (Cka1) Negatively Regulates RNA Polymerase II Transcription through Phosphorylation of Positive Cofactor 4 (PC4).
Not available
S-EPMC9409219 | biostudies-literature
UnknownPeptide-protein interactions suggest that acetylation of lysines 381 and 382 of p53 is important for positive coactivator 4-p53 interaction.
Not available
S-EPMC3137081 | biostudies-literature
Methylation profilingChromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4 (RRBS)
Chromatin protein positive coactivator 4 (PC4) has multiple functions, including chromatin compaction. However, its role in immune cells is largely unknown. We show that PC4 orchestrates chromatin structure and gene expression in mature B cells. B-cell specific PC4-deficient mice showed impaired pro...
ORGANISM(S): Mus musculus 
2020-12-22 | GSE163216 | GEO
GenomicsChromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4 (ChIP-seq)
B cell development is orchestrated by various transcription factors collaborating with chromatin remodelers that determine the genomic architecture. However, chromatin regulation in mature B cells is still poorly understood. Here, we show the critical function of positive coactivator 4 (PC4), a bona...
ORGANISM(S): Mus musculus 
2020-12-22 | GSE145951 | GEO
TranscriptomicsChromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4 (Agilent microarrays)
B cell development is orchestrated by various transcription factors collaborating with chromatin remodelers that determine the genomic architecture. However, chromatin regulation in mature B cells is still poorly understood. Here, we show the critical function of positive coactivator 4 (PC4), a bona...
ORGANISM(S): Mus musculus 
2020-12-22 | GSE145952 | GEO
UnknownA biochemical and biophysical model of G-quadruplex DNA recognition by positive coactivator of transcription 4.
Not available
S-EPMC5465483 | biostudies-literature
GenomicsChromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4 (RRBS)
Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4 (RRBS)
PRJNA685217 | ENA
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