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ProteomicsReduced structural rigidity of MDMX protein enhances binding to TP53 mRNA
The two murine double minute (MDM) family members, MDM2 and MDMX are a well-established negative regulator of p53 activity. Under DNA damage conditions, MDM2 and MDMX are phosphorylated near their RING domains (serine 395 at MDM2 and serine 403 at MDMX) and switch to act as p53 positive regulators. ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD060074 | Pride
Human Mdmx-mdm2 interaction P53 mrna stabilization Ring domain Hdx-ms mapping Lc-ms/ms 
UnknownDibasic Derivatives of Phenylcarbamic Acid as Prospective Antibacterial Agents Interacting with Cytoplasmic Membrane.
Not available
S-EPMC7168207 | biostudies-literature
TranscriptomicsRibosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts
Diamond Blackfan Anemia (DBA) is associated with developmental defects and profound anemia. Mutations in genes encoding a ribosomal protein of the small (e.g. Rps19) or large (e.g. Rpl11) ribosomal subunit are found in over half of these patients. The mutations cause ribosomal haploinsufficiency, ...
ORGANISM(S): Mus musculus 
2011-11-14 | E-GEOD-22903 | biostudies-arrayexpress
UnknownImpact of the Types and Relative Quantities of IGHV Gene Mutations in Predicting Prognosis of Patients With Chronic Lymphocytic Leukemia.
Not available
S-EPMC9315922 | biostudies-literature
UnknownThe Structure-Antimicrobial Activity Relationships of a Promising Class of the Compounds Containing the N-Arylpiperazine Scaffold.
Not available
S-EPMC6273431 | biostudies-literature
UnknownTelomeric IGH losses detectable by fluorescence in situ hybridization in chronic lymphocytic leukemia reflect somatic VH recombination events.
Not available
S-EPMC1867431 | biostudies-literature
UnknownThe SORL1 p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer's disease.
Not available
S-EPMC11406263 | biostudies-literature
TranscriptomicsTranscription profiling of human Chronic Lymphocytic Leukemia cells with mutated and unmutated IGHV
High Expression of Lymphocyte-Activation Gene 3 in Chronic Lymphocytic Leukemia Cells is Associated with Unmutated IGHV and Reduced Treatment-Free Survival
ORGANISM(S): Homo sapiens 
2009-09-17 | E-TABM-696 | biostudies-arrayexpress
UnknownIdentification of Clinically Relevant Subgroups of Chronic Lymphocytic Leukemia Through Discovery of Abnormal Molecular Pathways.
Not available
S-EPMC8273263 | biostudies-literature
UnknownBinding of histone H1 to DNA is differentially modulated by redox state of HMGB1.
Not available
S-EPMC3923860 | biostudies-literature
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