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UnknownPathogenic Leptospires Modulate Protein Expression and Post-translational Modifications in Response to Mammalian Host Signals.
Not available
S-EPMC5553009 | biostudies-literature
TranscriptomicsmRNA sequencing of two brain regions (prefrontal cortex and hippocampus) and left myocardial tissue in mice with chronic heart failure vs. sham-operated control mice
After induction of ischemic chronic heart failure (CHF), mice exhibited depression-like behavior, in terms of increased anhedonia, and decreased both exploratory activity and interest in novelty. On histology, ischemic CHF mice showed no alterations in overall cerebral morphology. To further evaluat...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-55280 | biostudies-arrayexpress
TranscriptomicsTLR signalling induced by bacterial RNA vs R848
Murine dendritic cells were derived from bone-marrow of 4 mice using GM-CSF. The DC were treated with RNA from gram-positive bacteria Listeria monocytogenes packaged in DOTAP or TLR7 agonist R848. Negative controls were DOTAP with no RNA or mock.
ORGANISM(S): Mus musculus 
2012-05-08 | E-MTAB-1139 | biostudies-arrayexpress
UnknownB-cell activating factor BAFF as a novel alert marker for the immunological risk stratification after kidney transplantation.
Not available
S-EPMC8580904 | biostudies-literature
TranscriptomicsMolecular sequelae of Nampt Inhibition in Human Multiple Myeloma cell line
Evaluation of specific coordinated pattern of transcriptional events consistent with anti-myeloma activity of FK866 (chemical Nampt inhibitor) 3 samples were analyzed using as control the untreated cells. Treated cells were cultured in presence of FK866 at concentration of 10nM for 6 and 24 hours.
ORGANISM(S): Homo sapiens 
2012-11-05 | E-GEOD-35414 | biostudies-arrayexpress
GenomicsGenome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target [Seq]
Multiple myeloma (MM) is a hematopoietic malignancy characterised by the accumulation of neoplastic post-germinal centre, isotype-switched, long-lived plasma cell within the bone marrow. In genetic and clinical terms MM is highly heterogeneous and remains fatal. Here we present the first epigenomic ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-53215 | biostudies-arrayexpress
ProteomicsMitochondrial mutant Caenorhabditis elegans phosphoproteome
Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effect remain elusive. Here, we investigate the phosphoproteomic landscape of Caenorhabditis elegans with severe...
ORGANISM(S): Caenorhabditis elegans 
2019-02-13 | PXD011859 | Pride
Metabolism Caenorhabditis elegans Insulin signaling Complex i Mitochondria Mitochondrial deficiency Iis 
ProteomicsUrinary Glycosylated IGF2 peptides in association with CKD
Chronic kidney disease (CKD) is prevalent in 10% of world’s adult population, with Estimated Glomerular filtration rate (eGFR) and albuminuria employed in diagnosis. Role of protein glycosylation in causal mechanisms of CKD progression is largely unknown. Aim of this study was to identify urinary O-...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD039829 | Pride
Ckd  egfr  post translational modifications  ptms  glycosylation  urine  peptidomics  glyco-peptide  igf2 
UnknownA community-based lung cancer rapid tissue donation protocol provides high-quality drug-resistant specimens for proteogenomic analyses.
Not available
S-EPMC6943158 | biostudies-literature
ProteomicsCardioprotection by selective SGLT2 inhibitors in a non-diabetic mouse model of myocardial ischemia/reperfusion injury: a class or a drug effect?
Major clinical trials with sodium glucose co-transporter-2 inhibitors (SGLT-2i) exhibit protective effects against heart failure events, whereas inconsistencies regarding the cardiovascular death outcomes are observed. Therefore, we aimed to compare the selective SGLT-2i empagliflozin (EMPA), dapagl...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-17 | MSV000088582 | MassIVE
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