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TranscriptomicsCMV-Specific CD8+ Memory T Cells Re-Emerge After Viral Challenge And Recapitulate CMV Immunity Under Various Adoptive Transfer Conditions
Reconstitution of cytomegalovirus (CMV)-specific immunity following transplant remains a primary clinical objective to prevent CMV disease, and adoptive immunotherapy of CMV-specific T cells can be an effective therapeutic approach. Due to the persistence of CMV, most CMV-specific CD8+ T cells becom...
ORGANISM(S): Mus musculus 
2015-01-28 | E-GEOD-61927 | biostudies-arrayexpress
UnknownMatrix M(TM) adjuvanted virosomal H5N1 vaccine induces balanced Th1/Th2 CD4(+) T cell responses in man.
Not available
S-EPMC4896793 | biostudies-literature
TranscriptomicsThe role of antigen presenting cells in the induction of HIV-1 latency in resting CD4+ T-cells
BACKGROUND: Combination antiretroviral therapy (cART) is able to control HIV-1 viral replication, however long-lived latent infection in resting memory CD4+ T-cells persist. The mechanisms for establishment and maintenance of latent infection in resting memory CD4+ T-cells remain unclear. Previously...
ORGANISM(S): Homo sapiens 
2015-12-23 | E-GEOD-70106 | biostudies-arrayexpress
TranscriptomicscDNA microarray expression profile during fiber elongation between G. hirsutum and G. barbadense
Sea-island cotton (Gossypium barbadense L.) has superior fiber quality properties such as length, fineness and strength, while Upland cotton (Gossypium hirsutum L.) is characterized by high yield. To reveal features of Upland cotton and Sea-island cotton fiber cells, differential genes expression pr...
ORGANISM(S): Gossypium hirsutum 
2012-05-23 | E-GEOD-18028 | biostudies-arrayexpress
ProteomicsIdentification of cGAS post-translational modifications
DNA derived from the genetic material of pathogens or from cellular DNA damage provides a molecular pattern that can be sensed by pattern-recognition receptors of the mammalian innate immune system. In recent years, the cyclic GMP-AMP synthase (cGAS) protein has been characterized as a primary cytos...
ORGANISM(S): Homo Sapiens 
2020-05-08 | PXD017133 | panorama
TranscriptomicsTranscription profiling of human CD4+ leukemia Jurkat T-cells in which the PI3K pathway is constitutively turned-on and FOXO1 transcriptional activity strongly repressed
One major effect of PI3-kinase activation downstream of the serine/threonine kinase Akt is the phosphorylation of the transcription factor FOXO1 and its neutralization. FOXO1 has several ubiquitous targets genes in many cell types that control cell quiescence, oxydative stress or apoptosis. However,...
ORGANISM(S): Homo sapiens 
2008-12-01 | E-TABM-391 | biostudies-arrayexpress
UnknownConserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137L.
Not available
S-EPMC3675563 | biostudies-literature
TranscriptomicsRNAi knock-down of VSG in T. brucei for 1 or 3 days
As an additional strategy for investigating T. brucei transcriptome responsiveness, the mRNA of a highly important protein, the variant surface glycoprotein (VSG) the major surface protein in the bloodstream stage, was suppressed with RNAi. VSG RNAi results in arrest of cell cycle progression...
ORGANISM(S): Trypanosoma brucei 
2008-06-26 | E-MEXP-1528 | biostudies-arrayexpress
TranscriptomicsIdentification of miRNAs regulated by TGF-b in human CD8+ T cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-46325 | biostudies-arrayexpress
TranscriptomicsModulation of transcriptional and inflammatory responses in murine macrophages by the Mycobacterium tuberculosis mammalian cell entry (Mce) 1 complex.
The outcome of many infections depends on the initial interactions between agent and host. Aiming at elucidating the effect of the M. tuberculosis Mce1 protein complex on host transcriptional and immunological responses to infection with M. tuberculosis, RNA from murine macrophages at 15, 30, 60 min...
ORGANISM(S): Mus musculus 
2011-10-05 | E-TABM-1170 | biostudies-arrayexpress
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