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MetabolomicsFeatures of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficit...
2024-01-12 | MTBLS850 | MetaboLights
MetabolomicsSARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces ...
2021-06-11 | MTBLS2840 | MetaboLights
ProteomicsLongitudinal multi-omics analysis of convalescent individuals with respiratory sequelae 6–36 months after COVID-19
This study presents a longitudinal multi-omics analysis of COVID-19 convalescents with respiratory sequelae, spanning 6–36 months post-infection. The integrating proteomic and metabolomic profiling uncovers persistent molecular alterations, impaired diffusing capacity for carbon monoxide, and propos...
ORGANISM(S): Homo Sapiens 
2025-02-23 | PXD061113 |
Proteomics‘The long tail of Covid 19’ - The detection of a prolonged inflammatory response after a SARS-CoV-2 infection in asymptomatic and mildly affected patients
‘Long Covid’ or medical complications associated with a post SARS Covid 2 infection, are a significant post-viral complication that is being more and more commonly reported in patients. Therefore, there is an increasing need to understand the disease mechanisms, identify drug targets and inflammato...
ORGANISM(S): Homo Sapiens 
2021-01-21 | PXD022159 | panorama
MetabolomicsSequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID

The post-acute sequelae of COVID-19 (PASC), also known as long COVID, is often associated with debilitating symptoms and adverse multisystem consequences. We obtain plasma samples from 117 individuals during and 6 mth following their acute phase of infection to comprehensively profile and as...

2024-02-23 | MTBLS7337 | MetaboLights
TranscriptomicsA distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection
This study included single-cell RNA-seq and scATAC-seq data from PBMCs from 12 COVID-19 individuals at acute infection.
ORGANISM(S): Homo sapiens 
2026-08-28 | E-MTAB-13745 | biostudies-arrayexpress
TranscriptomicsMultiple Early Factors Anticipate Post-Acute COVID-19 Sequelae
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk-factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation of 309 COVID-19 patients from initial diagnosis to convalescence (2...
ORGANISM(S): Homo sapiens 
2022-02-01 | E-MTAB-10129 | biostudies-arrayexpress
GenomicsA Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) (RECOVER NEURO)
A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) (RECOVER NEURO)
PRJNA1476259 | ENA
GenomicsA Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) (RECOVER NEURO)
A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) (RECOVER NEURO)
PRJNA1476260 | ENA
ProteomicsHIV/SARS-CoV-2 co-infection mediated proteomic changes in CNS potentiate neuro-HIV
Coronavirus disease 2019 (COVID-19) survivors frequently experience a wide range of symptoms known as post-acute sequelae of SARS-CoV-2 (PASC) or long COVID. Importantly, complications arising from microvascular dysfunction, blood-brain barrier (BBB) disruption, and chronic neuroinflammation have be...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD043206 | Pride
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