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MetabolomicsUntargetted lipidomics dataset: LC-MS analysis in two postmortem brain areas of healthy individuals and schizophrenia patients.

Schizophrenia is a common mental illness. It is a complex disorder with many symptoms and cognitive impairments. Despite extensive study, the molecular mechanisms of this disease are still unknown. Present time studies on the lipid composition of the human brain are extremely fragmented. Of the p...

2024-06-04 | MTBLS8955 | MetaboLights
MetabolomicsRole of breast milk lipid composition in postnatal brain development.

Lipids in the brain play a crucial role as structural and signaling molecules, accounting for approximately 60% of the brain’s dry weight. Several lipid classes exhibit concentration profile differences between humans and other species, including closely related primates, with the most pronounced...

2025-09-25 | MTBLS12481 | MetaboLights
TranscriptomicsGenome-wide Expression Assay Comparison Across Frozen and Fixed Postmortem Brain Tissue Samples
Comparison between in vitro transcription- and cDNA-mediated annealing, selection and ligation (DASL)-based assays on brain-specific reference RNA, and postmortem frozen and formalin fixed brain tissue from autistic and control cases. Investigation of data preprocessing techniques for DASL-assayed ...
ORGANISM(S): Homo sapiens 
2012-04-02 | E-GEOD-28475 | biostudies-arrayexpress
TranscriptomicsDNA methylation in postmortem brain samples from autism cases and controls
We used the Illumina 450KMethylation BeadChip to measure DNA methylation at 485,512 loci across the genome for 40 postmortem brain samples. The purpose of our study was to identify differentially methylated regions (DMRs) associated with autism. Samples included 16 temporal cortex brain tissue sampl...
ORGANISM(S): Homo sapiens 
2013-12-12 | E-GEOD-53162 | biostudies-arrayexpress
ProteomicsProteomic profiling of postmortem prefrontal cortex tissue of suicide completers
A total of 36 postmortem brain samples (23 suicide completers, 13 control sudden death) were collected. We evaluated the proteome profile in the prefrontal cortex (Brodmann area 9, 10) with TMT-based quantification using LC-MS/MS. Several bioinformatics tools were used to elucidate biological mechan...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD029845 | Pride
Suicide Proteomics Tandem mass tag Postmortem brain Lc-ms/ms 
TranscriptomicsBulk RNA-seq of postmortem human prefrontal cortex and cerebellum brain tissues
Analyzing brain region differences for postmortem Alzheimer's disease tissues.
ORGANISM(S): Homo sapiens 
2024-06-30 | E-MTAB-14167 | biostudies-arrayexpress
TranscriptomicsExpression mRNA data from human postmortem putamen samples measured using the NanoString nCounter platform
Background: Molecular adaptations in the striatum mediated by dopamine (DA) denervation or Levodopa (L-dopa) treatment have been implicated with the motor deficits found in Parkinson’s disease (PD). Alterations in glutamatergic neurotransmission and anti-oxidant mechanisms are reported to play imp...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-77666 | biostudies-arrayexpress
TranscriptomicsExpression miRNA data from human postmortem putamen samples measured using the NanoString nCounter platform
Background: Molecular adaptations in the striatum mediated by dopamine (DA) denervation or Levodopa (L-dopa) treatment have been implicated with the motor deficits found in Parkinsonâ??s disease (PD). Alterations in glutamatergic neurotransmission and anti-oxidant mechanisms are reported to play imp...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-77667 | biostudies-arrayexpress
ProteomicsProteomics of 2 postmortem Human Brain Regions for Identification of Cognitive Resilience Factors
We implemented an integrative systems-level analysis of multi-region postmortem human brain proteomics derived from the Religious Order and Rush Memory and Aging Project (ROSMAP) to identify proteins and pathways significantly altered in resilient cases. ROSMAP is an information-rich longitudinal co...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD040224 | Pride
Human brain Dlpfc Itc Proteome discoverer 
GenomicsFramingham Heart Study RNA sequencing in postmortem brain tissue
Framingham Heart Study RNA sequencing in postmortem brain tissue
PRJNA763280 | ENA
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