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TranscriptomicsAnalysis of on-chip hybridization kinetics for optimization of gene expression experiments.
DNA microarray technology is a powerful tool for getting the overview of gene expression in biological samples. Although the successful application of microarray-based expression analysis was demonstrated in a number of applications, the main problem with this approach is the fact that expression le...
ORGANISM(S): Mus musculus 
2007-09-29 | E-GEOD-7574 | biostudies-arrayexpress
TranscriptomicsHtrA1-dependent proteolysis of TGF-M-NM-2 controls both neuronal maturation and developmental survival
Transforming growth factor-M-NM-2 (TGF-M-NM-2) signalling controls a number of cerebral functions and dysfunctions including synaptogenesis, amyloid-M-NM-2 accumulation, apoptosis and excitotoxicity. Using cultured cortical neurons prepared from either wild type or transgenic mice over-expressing a ...
ORGANISM(S): Homo sapiens 
2008-04-15 | E-GEOD-11162 | biostudies-arrayexpress
TranscriptomicsIncrease in membrane cholesterol of neurons in culture recapitulates AlzheimerM-bM-^@M-^Ys disease early phenotypes.
Levels of membrane-associated cholesterol were shown to be increased in the brain of individuals with sporadic AlzheimerM-bM-^@M-^Ys disease (AD) and correlated with the severity of the disease. We previously found that heavy membrane cholesterol burden promotes amyloid precursor protein (APP) endoc...
ORGANISM(S): Rattus norvegicus 
2015-01-15 | E-GEOD-46221 | biostudies-arrayexpress
TranscriptomicsAge and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Recombinant tissue-type plasminogen activator (tPA) is the fibrinolytic drug of choice to treat stroke patients. However, a growing body of evidence indicates that besides its beneficial thrombolytic role, tPA can also have a deleterious effect on the ischaemic brain. Although ageing influences stro...
ORGANISM(S): Mus musculus 
2009-08-23 | E-GEOD-9004 | biostudies-arrayexpress
UnknownTs66Yah, a mouse model of Down syndrome with improved construct and face validity.
Not available
S-EPMC9789398 | biostudies-literature
UnknownDemyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.
Not available
S-EPMC6605244 | biostudies-literature
UnknownModifications of the endosomal compartment in fibroblasts from sporadic Alzheimer's disease patients are associated with cognitive impairment.
Not available
S-EPMC9929231 | biostudies-literature
UnknownIncreasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.
Not available
S-EPMC4280040 | biostudies-literature
UnknownCombined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer's disease.
Not available
S-EPMC5537644 | biostudies-literature
UnknownAaTs-1: A Tetrapeptide from Androctonus australis Scorpion Venom, Inhibiting U87 Glioblastoma Cells Proliferation by p53 and FPRL-1 Up-Regulations.
Not available
S-EPMC8704564 | biostudies-literature
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