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TranscriptomicsTranscription profiling of human early stage non-small cell lung carcinoma to refine prognosis for adjuvant therapy
Abstract from paper - Potti A, et al Experiment Overall Design: Retrospective analysis of approximately 200 samples obtained from Duke, ACOSOG and CALGB to develop a Lung metagene predictor that would then be used to assess risk of recurrence and thus identify high risk patients with stage Ia non-sm...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3593 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of breast cancer samples to predict response to anthracycline/taxane chemotherapy .
EORTC 10994 phase III breast cancer clinical trial comparing FEC (5-fluorouracil, cyclophosphamide, epirubicin) with ET (epirubicin, docetaxel). 161 needle biopsies of locally advanced or large operable breast tumours were hybridised to Affymetrix X3P chips. The array data from the ER negative ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6861 | biostudies-arrayexpress
TranscriptomicsGenetic Heterogeneity in Mouse Mammary Tumors
Human cancers result from a complex series of genetic alterations resulting in heterogeneous disease states. Dissecting this heterogeneity is critical for understanding underlying mechanisms and providing opportunities for therapeutics matching the complexity. Mouse models of cancer have generally b...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-15904 | biostudies-arrayexpress
TranscriptomicsA 50-Gene Predictor of Recurrence as a Guide to Therapy in Early-Stage Colon Cancer.
Gene expression profiles reflect unique aspects of individual biologic phenotypes and may characterize the heterogeneity of solid tumors. Using previously-described methodologies that employ DNA microarray data, a 50-gene expression profile (metagene) that predicts risk of recurrence in early stage ...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-10402 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human growing breast cancer cell lines
Gene expression analysis on growing breast cancer cell lines. Experiment Overall Design: see Bild, A. et.al.
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3156 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mammary epithelial cells expressing oncogenes (or GFP control)
Signatures of Oncogenic Pathway Deregulation in Human Cancers; The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3151 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ovarian cancer samples
Signatures of Oncogenic Pathway Deregulation in Human Cancers. The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3149 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancers
Signatures of Oncogenic Pathway Deregulation in Human Cancers. The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3143 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung cancers to identify signatures that reflect the activation status of oncogenic pathways
Signatures of Oncogenic Pathway Deregulation in Human Cancers. The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3141 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast tumors to identify age-specific differences of oncogenic pathway deregulation
Breast cancer arising in young women has a poorer prognosis, is less likely to be hormone sensitive, and represents a particularly challenging clinical entity. The biology driving the aggressive nature of breast cancer arising in young women has yet to be defined. Among 784 patients with early stag...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7849 | biostudies-arrayexpress
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