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ProteomicsSARS-CoV-2 Evades immune detection in Alveolar Macrophages
Respiratory infections, like the current pandemic SARS-CoV-2 virus, target the epithelial cells in the respiratory tract. However, alveolar macrophages (AMs) are tissue-resident macrophages located within the alveoli of the lung and they play a key role in the early phases of an immune response to r...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD021685 | Pride
Sars-cov-2 Prm Alveolar macrophages 
ProteomicsProtein composition of the subretinal fluid suggest selective diffusion of vitreous proteins in retinal detachment
Purpose: To study the proteome of the subretinal fluid (SRF) from rhegmatogenous retinal detachment (RRD) in search for novel markers for improved diagnosis and prognosis of RRD. Methods: Human undiluted SRF obtained during vitrectomy for primary RRD using a 41G needle (n = 24) was analyzed and comp...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD019159 | Pride
Retinal detachment Subretinal fluid Vitreous humor Eye 
ProteomicsProteomics of Fuchs Endothelial Corneal Dystrophy support that the extracellular matrix of Descemet¹s membrane is Disordered
Fuchs’ endothelial corneal dystrophy is major corneal disorder in the western world affecting the innermost part of the cornea, which leads to visual impairment. The morphological changes observed in Fuchs’ endothelial corneal dystrophy is well described, however, much less in known of the pathology...
ORGANISM(S): Homo sapiens (Human) 
2014-05-27 | PXD000746 | Pride
Itraq quantification Fuchs' endothelial corneal dystrophy Xic quantification 
ProteomicsProtein accumulation post-LASIK surgery in granular corneal dystrophy type II patients involves altered proteolytic processing of transforming growth factor beta-induced protein (TGFBIp)
his study present the protein profile of diseased cornea from granular corneal dystrophy patients developing protein accumulation after LASIK surgery. Extracted ion chromatography (XIC) label free quantification was perform using Mascot Distiller software. In addition, 2D-PAGE followed by western bl...
ORGANISM(S): Homo sapiens (Human) 
2016-02-19 | PXD001997 | Pride
Cornea Tripletof 5600+ Xic quantification 2d-page Granular corneal dystrophy 
ProteomicsProteomic profiling of TGFBIp-null mouse corneas reveals minor changes in the extracellular matrix composition supportive of TGFBI knockdown as therapy against TGFBI-linked corneal dystrophies
TGFBIp is a constituent of the extracellular matrix in many human tissues including the cornea, where it is one of the most abundant proteins expressed. TGFBIp interacts with type I, II, IV, VI and XII collagens as well as several members of the integrin family, suggesting that it plays an important...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-14 | PXD006494 | Pride
Ecm Tgfbip Cornea Periostin Itraq Lc-ms/ms 
ProteomicsProtein accumulation post-LASIK surgery in granular corneal dystrophy type II patients involves altered proteolytic processing of transforming growth factor beta-induced protein (TGFBIp)
his study present the protein profile of diseased cornea from granular corneal dystrophy patients developing protein accumulation after LASIK surgery. Extracted ion chromatography (XIC) label free quantification was perform using Mascot Distiller software. In addition, 2D-PAGE followed by western bl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080219 | MassIVE
ProteomicsProtein composition of TGFBI-R124C and TGFBI-R555W associated aggregates suggests multiple mechanisms leading to Lattice and Granular corneal dystrophy
Transforming Growth Factor Beta-induced (TGFBI)-related dystrophies constitute the most common heritable forms of corneal dystrophy worldwide. However, other than the underlying genotypes of these conditions, a limited knowledge exists of the exact pathomechanisms of these disorders. This study expa...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079985 | MassIVE
OtherProteomics of Fuchs- Endothelial Corneal Dystrophy support that the extracellular matrix of Descemet-s membrane is disordered.
Data from ProteomeXchange, PXD ID: PXD000746. Experiment: label-free, file: 2012-10-05 - ETP - Fuchs - Control - 3-2.mgf. Published as part of J Proteome Res. 2014 May 21 . From the Abstract: {{i}} Fuchs- endothelial corneal dystrophy (FECD) is a major corneal disorder affecting the innermost part ...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310000394 | GPMDB
Resource Reanalysis 
OtherUnconditioned commercial embryo culture media contain a large variety of non-declared proteins: a comprehensive proteomics analysis.
Data from ProteomeXchange, PXD ID: PXD001174. Experiment: Vitrolife G-1 Plus - 1ug, file: 2014-01-28 - TFD - Vitrolife G-1 Plus - 1ug - 3.mgf. Published as part of Hum Reprod. 2014 Aug 27 . From the Abstract: {{i}} STUDY QUESTION: Which non-declared proteins (proteins not listed on the composition ...
ORGANISM(S): Homo_sapiens_viruses, Human, Acholeplasma_laidlawii_pg_8a,escherichia_coli_k_12_substr__mg1655,escherichia_coli_o157_h7_sakai,escherichia_coli_se11,mycoplasma_fermentans_jer,mycoplasma_hominis_atcc_23114,mycoplasma_hyorhinis_gdl_1 
GPM11210029252 | GPMDB
Resource Reanalysis 
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