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MetabolomicsMetabonomics uncovers a reversible proatherogenic lipid profile during infliximab therapy of inflammatory bowel disease

BACKGROUND: One-third of inflammatory bowel disease (IBD) patients show no response to infliximab (IFX) induction therapy, and approximately half of patients responding become unresponsive over time. Thus, identification of potential treatment response biomarkers are of great cl...

2022-01-13 | MTBLS239 | MetaboLights
Unknown"Nine Dimensions": A multidisciplinary approach for community engagement in a complex postwar border region as part of the targeted malaria elimination in Karen/Kayin State, Myanmar.
Not available
S-EPMC6343222 | biostudies-literature
MetabolomicsMetabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals
This study employs spectroscopy-based metabolic profiling of fecal extracts from healthy subjects and patients with active or inactive ulcerative colitis (UC) and Crohn's disease (CD) to substantiate the potential use of spectroscopy as a non-invasive diagnostic tool and to characterize the fecal me...
2017-02-07 | MTBLS237 | MetaboLights
ProteomicsGlobal Chromatin Profiling Dataset of Chemical Perturbations in Multiple Biological Backgrounds
The Library of Integrated Network-based Cellular Signatures (LINCS) Program aims to create a network-based understanding of biology by cataloging changes in gene expression and other cellular processes that occur when cells are exposed to a variety of perturbing agents. The goal of this project is t...
ORGANISM(S): Homo Sapiens 
2022-03-02 | PXD017459 | panorama
ProteomicsPhospho-proteomic Profiling Dataset of Chemical Perturbations in Multiple Biological Backgrounds
The Library of Integrated Network-based Cellular Signatures (LINCS) Program aims to create a network-based understanding of biology by cataloging changes in gene expression and other cellular processes that occur when cells are exposed to a variety of perturbing agents. The goal of this project is t...
ORGANISM(S): Homo Sapiens 
2022-03-02 | PXD017458 | panorama
GenomicAutopsy-Confirmed Parkinson Disease GWAS Consortium (APDGC)

The APDGC was formed to conduct a genome-wide association study in individuals with neuropathologically confirmed Parkinson Disease (PD) and neuropathologically normal controls. The rationale for the study is that including only cases and controls with neuropathologically confirmed disease status...

phs000394 | dbGaP
TranscriptomicsTranscription profiling of homozygous Commd1 null mouse embryos to elucidate the underlying mechanism leading to embryonic lethality
A gene expression study using microarray analysis was performed to elucidate the underlying mechanism leading to embryonic lethality in homozygous Commd1 null (Commd1-/-) mouse embryos. A gene expression profile of 9.5 dpc Commd1-/- embryos were generated and were compared to a gene expression profi...
ORGANISM(S): Mus musculus 
2006-09-01 | E-MEXP-832 | biostudies-arrayexpress
MetabolomicsIsotopomer analysis of MCF-7 breast cancer cell line incubated with 13C labelled glucose (NMR assay)
MS and NMR are two of the most powerful spectroscopic techniques used in the field of fluxomics, to analyze the flux distributions in cellular metabolomic pathways. Both of them possess pros and cons, such as, MS being the most sensitive and low-cost technique, while needs extensive sample processin...
2018-05-02 | MTBLS241 | MetaboLights
GenomicForegut Microbiome in Development of Esophageal Adenocarcinoma

The distal esophagus is an important anatomical area where gastric acid reflux can cause reflux esophagitis (RE), Barrett's esophagus (BE) (intestinal metaplasia), and esophageal adenocarcinoma (EA). The incidence of EA has increased 6-fold in the U.S. since the 1970s, parallel to a significa...

phs000260 | dbGaP
TranscriptomicsChIP-chip of MCF7 Sox2 regulatory region 2 transcription activity reporter unresponsive and reporter responsive breast cancer cells
We found that MCF7 and ZR751 Sox2-expressing breast cancer cell lines comprise of cells with heterogeneous Sox2 transcription activity reporter response. A small subset of Sox2 reporter responsive cells are more tumourigenic than the bulk Sox2 reporter unresponsive cells. We questioned whether Sox2 ...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-61703 | biostudies-arrayexpress
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