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UnknownRule-Based Pruning and In Silico Identification of Essential Proteins in Yeast PPIN.
Not available
S-EPMC9454873 | biostudies-literature
ProteomicsExtensive Rewiring of the the Epidermal Growth Factor Receptor EGFR Networks in Colorectal Cancer Cells Expressing Transforming Levels of Oncogenic KRASG13D
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects PPIN structure and...
ORGANISM(S): Homo sapiens (Human) 
2019-12-04 | PXD016431 | Pride
Extensive rewiring of the the epidermal growth factor receptor egfr networks in colorectal cancer cells expressing transforming levels of oncogenic krasg13d 
ProteomicsNuclear phosphatidylinositol (3,4,5) triphosphate interactome uncovers an enrichment in nucleolar proteins
Polyphosphoinositides (PPIn) play essential functions as lipid signalling molecules and many of their functions have been elucidated in the cytoplasm. However, PPIns are also intranuclear where they contribute to chromatin remodelling, transcription and mRNA splicing. The PPIn, phosphatidylinositol ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-28 | PXD020870 | Pride
Poly(adp-ribose) polymerase 1 (parp1) 4 Nucleolus 5)p3 interactome Nuclear phosphoinisitides Heterogeneous nuclear ribonucleoprotein u (hnrnpu/saf-a) Ptdins (3 
UnknownProbing the subcellular distribution of phosphatidylinositol reveals a surprising lack at the plasma membrane.
Not available
S-EPMC7054989 | biostudies-literature
UnknownSAF-A/hnRNP U binds polyphosphoinositides via a lysine rich polybasic motif located in the SAP domain.
Not available
S-EPMC10082394 | biostudies-literature
UnknownPolyphosphoinositide-Binding Domains: Insights from Peripheral Membrane and Lipid-Transfer Proteins.
Not available
S-EPMC8284841 | biostudies-literature
UnknownComparison of modules of wild type and mutant Huntingtin and TP53 protein interaction networks: implications in biological processes and functions.
Not available
S-EPMC3669416 | biostudies-literature
UnknownExtensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS<sup>G13D</sup>.
Not available
S-EPMC6981206 | biostudies-literature
UnknownDefining the subcellular distribution and metabolic channeling of phosphatidylinositol.
Not available
S-EPMC7054996 | biostudies-literature
UnknownDetection of spreader nodes in human-SARS-CoV protein-protein interaction network.
Not available
S-EPMC8428263 | biostudies-literature
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