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ProteomicsProteomic analysis of affinity-purified praja2 complexes
Praja2 is a RING E3 ubiquitin ligase, widely expressed in mammalian cells and tissues which is involved in essential aspects of cell physiology. Several signaling pathways are regulated by praja2. The stability of regulatory PKA subunits is directly regulated by Praja2, which binds and tethers cAMP-...
ORGANISM(S): Homo sapiens (Human) 
2026-06-25 | PXD033734 | Pride
Lc-ms-ms Praja2 Interactome 
ProteomicsDownregulation of RING ligase praja2 boosts receptor tyrosine kinases in kidney cancer
Clear cell renal cell carcinoma (ccRCC) is the most common variant of kidney cancer in the adult population. Late diagnosis, resistance to therapeutics and recurrence of metastatic lesions account for the highest mortality rate among kidney cancer patients. Identifying novel biomarkers for early can...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD034966 | Pride
Lc-ms-ms Praja2 Interactome 
TranscriptomicsLoss of the RING ligase praja2 boosts tyrosine kinase receptors in clear cell carcinoma
Background: Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer in the adult population. Late diagnosis, resistance to therapeutics and recurrence of metastatic lesions account for the highest mortality rate among kidney cancer patients. Identifying novel biomarkers for early ca...
ORGANISM(S): Mus musculus 
2024-02-01 | E-MTAB-13105 | biostudies-arrayexpress
TranscriptomicsDownregulation of RING ligase praja2 boosts receptor tyrosine kinases in kidney cancer
Clear cell renal cell carcinoma (ccRCC) is the most common variant of kidney cancer in the adult population. Late diagnosis, resistance to therapeutics and recurrence of metastatic lesions account for the highest mortality rate among kidney cancer patients. Identifying novel biomarkers for early can...
ORGANISM(S): Homo sapiens 
2023-08-13 | E-MTAB-11900 | biostudies-arrayexpress
GenomicsDownregulation of RING ligase praja2 boosts receptor tyrosine kinases in kidney cancer
Downregulation of RING ligase praja2 boosts receptor tyrosine kinases in kidney cancer
PRJEB54648 | ENA
GenomicsLoss of the RING ligase praja2 boosts tyrosine kinase receptors in clear cell carcinoma
Loss of the RING ligase praja2 boosts tyrosine kinase receptors in clear cell carcinoma
PRJEB63462 | ENA
UnknownDownregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer.
Not available
S-EPMC10879500 | biostudies-literature
UnknownPraja2 suppresses the growth of gastric cancer by ubiquitylation of KSR1 and inhibiting MEK-ERK signal pathways.
Not available
S-EPMC7906149 | biostudies-literature
UnknownPraja2 controls P-body assembly and translation in glioblastoma by non-proteolytic ubiquitylation of DDX6.
Not available
S-EPMC12069581 | biostudies-literature
UnknownThe TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation.
Not available
S-EPMC8126939 | biostudies-literature
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