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ProteomicsLong non-coding RNA Neat1 is a key of translational regulator in hypoxia
Internal ribosome entry sites (IRESs) drive translation initiation during stress. In response to hypoxia, (lymph)angiogenic factors responsible for tissue revascularization in ischemic diseases are induced by the IRES-dependent mechanism. Here we searched for IRES trans-acting factors (ITAFs) active...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-03 | PXD024067 | Pride
Nanolc-ms/ms Translational control Hypoxia Cardiomyocyte Label-free quantitative proteomics 
ProteomicsMitochondrial ribosomal protein MRPS15 Is a component of cytosolic ribosomes and regulates translation in stressed cardiomyocytes
Regulation of mRNA translation is a crucial step in controlling gene expression in stressed cells, impacting many pathologies, including heart ischemia. In recent years, ribosome heterogeneity has emerged as a key control mechanism driving the translation of subsets of mRNAs. In this study, we inves...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050321 | Pride
Ribosome heterogeneity  mitochondrial ribosomal protein  translational control  ires  endoplasmic reticulum stress  cardiomyocyte  proteomics 
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