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GenomicsChIP-seq analysis of PRC2 core subunits in primary human erythroid progenitor cells
Polycomb Repressive Complex 2 (PRC2) plays crucial roles in transcriptional regulation and stem cell development. However, the context-specific functions associated with alternative subunits remain largely unexplored. Here we show that the related enzymatic subunits EZH1 and EZH2 undergo an expressi...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-59087 | biostudies-arrayexpress
TranscriptomicsRNA-seq transcriptional profiling in primary human erythroid progenitor cells upon shRNA-mediated knockdown of PRC2 core subunits
Polycomb Repressive Complex 2 (PRC2) plays crucial roles in transcriptional regulation and stem cell development. However, the context-specific functions associated with alternative subunits remain largely unexplored. Here we show that the related enzymatic subunits EZH1 and EZH2 undergo an expressi...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-59089 | biostudies-arrayexpress
GenomicsConvergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets [WGBS]
Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets [WGBS]
PRJNA967261 | ENA
GenomicsRNA-seq to determine PRC2 targets in the aging Drosophila brain.
RNA-seq to determine PRC2 targets in the aging Drosophila brain.
PRJNA432934 | ENA
GenomicsConvergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets [ChIP-Seq]
Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets [ChIP-Seq]
PRJNA1218460 | ENA
UnknownC10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels.
Not available
S-EPMC6889301 | biostudies-literature
GenomicsASXL1 Mutations Promote Myeloid Transformation Through Loss of PRC2-Mediated Gene Repression
Recurrent somatic ASXL1 mutations occur in patients with myelodysplasia (MDS), myeloproliferative neoplasms (MPN), and acute myeloid leukemia (AML), and are associated with adverse outcome. Despite the genetic and clinical data implicating ASXL1 mutations in myeloid malignancies, the mechanisms of t...
ORGANISM(S): Homo sapiens 
2012-08-21 | E-GEOD-38861 | biostudies-arrayexpress
UnknownMicroRNAs reinforce repression of PRC2 transcriptional targets independently and through a feed-forward regulatory network.
Not available
S-EPMC6360819 | biostudies-literature
GenomicsPolycomb-like 3 is a PRC2 component that supports embryonic stem cell self-renewal
Polycomb repressive complex 2 (PRC2) trimethylates lysine 27 of histone H3 (H3K27me3), which regulates gene expression and controls diverse biological transitions in development, embryonic stem cell (ESC) differentiation, and cancer. Here we show that Polycomb-like 3 (Pcl3) is a component of PRC2 t...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-28325 | biostudies-arrayexpress
GenomicsReciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP-XL crosslinking and affinity purification
Short-read sequencing of DNA fractions of the BioTAP-XL pull-downs on human EZH2 and interacting proteins. ChIP-seq-like pulldown/input samples
ORGANISM(S): Homo sapiens 
2014-02-01 | E-GEOD-53495 | biostudies-arrayexpress
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